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Gene: PLPP4 (phospholipid phosphatase 4) Homo sapiens
Symbol: PLPP4
Name: phospholipid phosphatase 4
Description: Exhibits diacylglycerol diphosphate phosphatase activity; identical protein binding activity; and phosphatidate phosphatase activity. Involved in phospholipid dephosphorylation and regulation of calcium ion import. Predicted to localize to plasma membrane. Biomarker of breast cancer; INTERACTS WITH 4,4'-sulfonyldiphenol; aflatoxin B1; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: diacylglycerol pyrophosphate like 2; diacylglycerol pyrophosphate phosphatase-like 2; DPPL2; MGC120299; MGC120300; phosphatidate phosphatase PPAPDC1A; phosphatidic acid phosphatase type 2 domain containing 1A; phosphatidic acid phosphatase type 2 domain-containing protein 1A; PPAPDC1; PPAPDC1A
Mus musculus (house mouse) : Plpp4 (phospholipid phosphatase 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Plpp4 (phospholipid phosphatase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plpp4 (phospholipid phosphatase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : PLPP4 (phospholipid phosphatase 4)
Canis lupus familiaris (dog) : PLPP4 (phospholipid phosphatase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plpp4 (phospholipid phosphatase 4)
Sus scrofa (pig) : PLPP4 (phospholipid phosphatase 4)
Chlorocebus sabaeus (African green monkey) : PLPP4 (phospholipid phosphatase 4)
Heterocephalus glaber (naked mole-rat) : Plpp4 (phospholipid phosphatase 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl10120,457,227 - 120,592,065 (+)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl10120,456,954 - 120,589,855 (+)EnsemblGRCh38hg38GRCh38
GRCh3810120,456,954 - 120,600,123 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710122,216,466 - 122,349,367 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610122,206,456 - 122,339,357 (+)NCBINCBI36hg18NCBI36
Celera10115,947,750 - 116,080,667 (+)NCBI
Cytogenetic Map10q26.12NCBI
HuRef10115,845,693 - 115,978,671 (+)NCBIHuRef
CHM1_110122,501,266 - 122,634,679 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PLPP4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351368
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.