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Gene: HDAC6 (histone deacetylase 6) Homo sapiens
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Symbol: HDAC6
Name: histone deacetylase 6
Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CPBHM; FLJ16239; HD6; JM21; PPP1R90
Orthologs:
Mus musculus (house mouse) : Hdac6 (histone deacetylase 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hdac6 (histone deacetylase 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hdac6 (histone deacetylase 6)
Pan paniscus (bonobo/pygmy chimpanzee) : HDAC6 (histone deacetylase 6)
Canis lupus familiaris (dog) : HDAC6 (histone deacetylase 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hdac6 (histone deacetylase 6)
Sus scrofa (pig) : HDAC6 (histone deacetylase 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,801,377 - 48,824,982 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X48,660,086 - 48,683,408 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,545,431 - 48,568,324 (+)NCBINCBI36hg18NCBI36
Build 34X48,416,735 - 48,439,629NCBI
CeleraX52,980,148 - 53,003,041 (-)NCBI
Cytogenetic MapXp11.23NCBI
HuRefX46,319,662 - 46,343,018 (+)NCBIHuRef
CHM1_1X48,690,928 - 48,714,536 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on HDAC6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351463
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.