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Gene: TOP1MT (DNA topoisomerase I mitochondrial) Homo sapiens
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Symbol: TOP1MT
Name: DNA topoisomerase I mitochondrial
Description: Predicted to have DNA topoisomerase type I (single strand cut, ATP-independent) activity. Predicted to be involved in DNA replication and DNA topological change. Localizes to mitochondrial nucleoid and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNA topoisomerase I, mitochondrial; mitochondrial DNA topoisomerase I; mitochondrial topoisomerase IB; topoisomerase (DNA) I, mitochondrial
Orthologs:
Mus musculus (house mouse) : Top1mt (DNA topoisomerase 1, mitochondrial)  MGI  Alliance
Rattus norvegicus (Norway rat) : Top1mt (DNA topoisomerase I mitochondrial)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Top1mt (DNA topoisomerase I mitochondrial)
Pan paniscus (bonobo/pygmy chimpanzee) : TOP1MT (DNA topoisomerase I mitochondrial)
Sus scrofa (pig) : TOP1MT (DNA topoisomerase I mitochondrial)
Chlorocebus sabaeus (African green monkey) : TOP1MT (DNA topoisomerase I mitochondrial)
Heterocephalus glaber (naked mole-rat) : Top1mt (DNA topoisomerase I mitochondrial)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl8143,304,384 - 143,359,979 (-)EnsemblGRCh38hg38GRCh38
GRCh388143,309,324 - 143,359,977 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378144,391,494 - 144,442,147 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368144,462,901 - 144,488,425 (-)NCBINCBI36hg18NCBI36
Build 348144,462,904 - 144,488,425NCBI
Celera8140,700,651 - 140,727,260 (-)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8139,629,915 - 139,695,642 (-)NCBIHuRef
CHM1_18144,431,738 - 144,482,220 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TOP1MT
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351494
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.