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Gene: MSRB3 (methionine sulfoxide reductase B3) Homo sapiens
Symbol: MSRB3
Name: methionine sulfoxide reductase B3
Description: Exhibits peptide-methionine (R)-S-oxide reductase activity and zinc ion binding activity. Involved in protein repair. Localizes to the endoplasmic reticulum and mitochondrion. Implicated in autosomal recessive nonsyndromic deafness 74.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DFNB74; DKFZp686C1178; FLJ36866; methionine-R-sulfoxide reductase B3; methionine-R-sulfoxide reductase B3, mitochondrial
Mus musculus (house mouse) : Msrb3 (methionine sulfoxide reductase B3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Msrb3 (methionine sulfoxide reductase B3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Msrb3 (methionine sulfoxide reductase B3)
Pan paniscus (bonobo/pygmy chimpanzee) : MSRB3 (methionine sulfoxide reductase B3)
Canis lupus familiaris (dog) : MSRB3 (methionine sulfoxide reductase B3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Msrb3 (methionine sulfoxide reductase B3)
Sus scrofa (pig) : MSRB3 (methionine sulfoxide reductase B3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381265,278,593 - 65,466,907 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371265,672,423 - 65,860,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361263,958,755 - 64,146,954 (+)NCBINCBI36hg18NCBI36
Build 341263,958,754 - 64,144,495NCBI
Celera1265,337,946 - 65,526,205 (+)NCBI
Cytogenetic Map12q14.3NCBI
HuRef1262,724,179 - 62,912,947 (+)NCBIHuRef
CHM1_11265,639,431 - 65,827,664 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MSRB3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351511
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.