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Gene: XK (X-linked Kx blood group) Homo sapiens
Symbol: XK
Name: X-linked Kx blood group
Description: This locus controls the synthesis of the Kell blood group 'precursor substance' (Kx). Mutations in this gene have been associated with McLeod syndrome, an X-linked, recessive disorder characterized by abnormalities in the neuromuscular and hematopoietic systems. The encoded protein has structural characteristics of prokaryotic and eukaryotic membrane transport proteins. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Kell blood group precursor (McLeod phenotype); kell complex 37 kDa component; KX; Kx antigen; Kx blood group antigen; MCLDS; membrane transport protein XK; NA; NAC; neuroacanthocytosis; neurocanthocytosis; truncated X-linked Kx blood group; X1k; XK, Kell blood group complex subunit (McLeod syndrome); XK-related protein 1; XKR1
Mus musculus (house mouse) : Xk (X-linked Kx blood group)  MGI  Alliance
Rattus norvegicus (Norway rat) : Xk (X-linked Kx blood group)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Xk (X-linked Kx blood group)
Pan paniscus (bonobo/pygmy chimpanzee) : XK (X-linked Kx blood group)
Canis lupus familiaris (dog) : XK (X-linked Kx blood group)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xk (X-linked Kx blood group)
Sus scrofa (pig) : XK (X-linked Kx blood group)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X37,685,686 - 37,732,130 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X37,545,133 - 37,591,383 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X37,430,052 - 37,476,322 (+)NCBINCBI36hg18NCBI36
Build 34X37,301,324 - 37,347,594NCBI
CeleraX41,682,795 - 41,729,061 (+)NCBI
Cytogenetic MapXp21.1NCBI
HuRefX35,290,888 - 35,336,107 (+)NCBIHuRef
CHM1_1X37,576,264 - 37,622,522 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on XK
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351512
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.