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Gene: RUNX3 (RUNX family transcription factor 3) Homo sapiens
Symbol: RUNX3
Name: RUNX family transcription factor 3
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription, DNA-templated; protein phosphorylation; and response to transforming growth factor beta. Localizes to cytosol; nucleolus; and nucleoplasm. Implicated in breast cancer (multiple); female reproductive organ cancer (multiple); in situ carcinoma; pancreatic cancer; and urinary bladder cancer. Biomarker of cholangiocarcinoma; ovary epithelial cancer; and thyroid gland papillary carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acute myeloid leukemia 2 protein; acute myeloid leukemia gene 2; AML2; CBF-alpha-3; CBFA3; core-binding factor subunit alpha-3; core-binding factor, runt domain, alpha subunit 3; FLJ34510; MGC16070; oncogene AML-2; PEA2 alpha C; PEA2-alpha C; PEBP2 alpha C; PEBP2-alpha C; PEBP2aC; polyomavirus enhancer-binding protein 2 alpha C subunit; runt related transcription factor 3; runt-related transcription factor 3; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; transcription factor AML2
Mus musculus (house mouse) : Runx3 (runt related transcription factor 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Runx3 (RUNX family transcription factor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Runx3 (RUNX family transcription factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : RUNX3 (RUNX family transcription factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Runx3 (RUNX family transcription factor 3)
Sus scrofa (pig) : RUNX3 (RUNX family transcription factor 3)
Chlorocebus sabaeus (African green monkey) : RUNX3 (RUNX family transcription factor 3)
Heterocephalus glaber (naked mole-rat) : Runx3 (RUNX family transcription factor 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl124,899,511 - 24,965,121 (-)EnsemblGRCh38hg38GRCh38
GRCh38124,899,511 - 24,965,158 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37125,226,002 - 25,291,648 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36125,098,589 - 25,164,088 (-)NCBINCBI36hg18NCBI36
Build 34124,971,363 - 25,001,674NCBI
Celera123,550,687 - 23,616,186 (-)NCBI
Cytogenetic Map1p36.11NCBI
HuRef123,479,020 - 23,544,351 (-)NCBIHuRef
CHM1_1125,339,525 - 25,404,974 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RUNX3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351530
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.