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Gene: LCMT1 (leucine carboxyl methyltransferase 1) Homo sapiens
Symbol: LCMT1
Name: leucine carboxyl methyltransferase 1
Description: Exhibits protein C-terminal carboxyl O-methyltransferase activity. Involved in several processes, including C-terminal protein methylation; negative regulation of protein complex assembly; and regulation of mitotic cell cycle spindle assembly checkpoint. Predicted to localize to the cytosol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: [phosphatase 2A protein]-leucine-carboxy methyltransferase; [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1; CGI-68; LCMT; PPMT1; protein phosphatase methyltransferase 1; protein-leucine O-methyltransferase
Mus musculus (house mouse) : Lcmt1 (leucine carboxyl methyltransferase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lcmt1 (leucine carboxyl methyltransferase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lcmt1 (leucine carboxyl methyltransferase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LCMT1 (leucine carboxyl methyltransferase 1)
Canis lupus familiaris (dog) : LCMT1 (leucine carboxyl methyltransferase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lcmt1 (leucine carboxyl methyltransferase 1)
Sus scrofa (pig) : LCMT1 (leucine carboxyl methyltransferase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381625,111,702 - 25,178,231 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371625,123,047 - 25,189,551 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361625,030,548 - 25,097,052 (+)NCBINCBI36hg18NCBI36
Build 341625,030,675 - 25,097,050NCBI
Celera1623,903,957 - 23,969,431 (+)NCBI
Cytogenetic Map16p12.1NCBI
HuRef1623,216,333 - 23,282,516 (+)NCBIHuRef
CHM1_11626,136,800 - 26,203,307 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on LCMT1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351587
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.