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Gene: SPANXA2 (SPANX family member A2) Homo sapiens
Symbol: SPANXA2
Name: SPANX family member A2
Description: Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A1 and appears to be a duplication of that locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cancer/testis antigen 11.1; Cancer/testis antigen 11.3; Cancer/testis-associated protein CTp11; CT11.1; CT11.3; nuclear-associated protein SPAN-Xa; Nuclear-associated protein SPAN-Xc; SPAN-X; SPANX; SPANX family member A; SPANX family, member A2; SPANX-A; SPANX-C; SPANXA; SPANXA1; SPANXC; sperm protein associated with the nucleus on the X chromosome A; Sperm protein associated with the nucleus on the X chromosome C; sperm protein associated with the nucleus, X chromosome, family member A2
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X141,589,708 - 141,590,772 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X140,677,835 - 140,678,899 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X140,505,498 - 140,506,567 (+)NCBINCBI36hg18NCBI36
Build 34X140,403,354 - 140,404,419NCBI
CeleraX141,072,897 - 141,073,962 (-)NCBI
Cytogenetic MapXq27.2NCBI
CHM1_1X140,588,966 - 140,589,993 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene Ontology Annotations
References - uncurated


miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SPANXA2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351593
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.