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Gene: TKTL1 (transketolase like 1) Homo sapiens
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Symbol: TKTL1
Name: transketolase like 1
Description: The protein encoded by this gene is a transketolase that acts as a homodimer and catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate. This reaction links the pentose phosphate pathway with the glycolytic pathway. Variations in this gene may be the cause of Wernicke-Korsakoff syndrome. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: TK 2; TKR; TKT2; transketolase 2; transketolase-2; transketolase-like 1; transketolase-like protein 1; transketolase-related protein
Orthologs:
Mus musculus (house mouse) : Tktl1 (transketolase-like 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tktl1 (transketolase-like 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tktl1 (transketolase like 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TKTL1 (transketolase like 1)
Canis lupus familiaris (dog) : TKTL1 (transketolase like 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tktl1 (transketolase like 1)
Sus scrofa (pig) : TKTL1 (transketolase like 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,295,674 - 154,330,363 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X153,523,979 - 153,558,713 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,177,345 - 153,211,894 (+)NCBINCBI36hg18NCBI36
Build 34X153,044,997 - 153,079,545NCBI
CeleraX153,685,095 - 153,719,771 (+)NCBI
Cytogenetic MapXq28NCBI
HuRefX142,101,239 - 142,134,950 (+)NCBIHuRef
CHM1_1X153,435,658 - 153,470,347 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TKTL1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351621
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.