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Gene: IDS (iduronate 2-sulfatase) Homo sapiens
Symbol: IDS
Name: iduronate 2-sulfatase
Description: This gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha-L-iduronate sulfate sulfatase; ID2S; iduronate 2-sulfatase 14 kDa chain; iduronate 2-sulfatase 42 kDa chain; idursulfase; MPS2; SIDS
Mus musculus (house mouse) : Ids (iduronate 2-sulfatase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ids (iduronate 2-sulfatase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ids (iduronate 2-sulfatase)
Pan paniscus (bonobo/pygmy chimpanzee) : IDS (iduronate 2-sulfatase)
Canis lupus familiaris (dog) : IDS (iduronate 2-sulfatase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ids (iduronate 2-sulfatase)
Sus scrofa (pig) : IDS (iduronate 2-sulfatase)
more info ...
Related Pseudogenes: IDSP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X149,476,990 - 149,505,354 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X148,560,295 - 148,586,884 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X148,368,206 - 148,394,698 (-)NCBINCBI36hg18NCBI36
Build 34X148,274,422 - 148,292,552NCBI
CeleraX148,909,049 - 148,935,639 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX137,513,419 - 137,540,564 (-)NCBIHuRef
CHM1_1X148,519,548 - 148,547,912 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on IDS
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351665
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.