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Gene: CFP (complement factor properdin) Homo sapiens
Symbol: CFP
Name: complement factor properdin
Description: This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BFD; complement factor P; PFC; PFD; properdin; properdin P factor, complement
Mus musculus (house mouse) : Cfp (complement factor properdin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cfp (complement factor properdin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cfp (complement factor properdin)
Pan paniscus (bonobo/pygmy chimpanzee) : CFP (complement factor properdin)
Canis lupus familiaris (dog) : CFP (complement factor properdin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cfp (complement factor properdin)
Sus scrofa (pig) : CFP (complement factor properdin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X47,623,282 - 47,630,305 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X47,483,612 - 47,489,704 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X47,368,569 - 47,374,648 (-)NCBINCBI36hg18NCBI36
Build 34X47,239,878 - 47,245,958NCBI
CeleraX51,678,874 - 51,684,967 (-)NCBI
Cytogenetic MapXp11.23NCBI
HuRefX45,196,561 - 45,202,654 (-)NCBIHuRef
CHM1_1X47,514,712 - 47,520,808 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CFP
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351689
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.