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Gene: CFP (complement factor properdin) Homo sapiens
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Symbol: CFP
Name: complement factor properdin
Description: This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BFD; complement factor P; PFC; PFD; properdin; properdin P factor, complement
Orthologs:
Mus musculus (house mouse) : Cfp (complement factor properdin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cfp (complement factor properdin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cfp (complement factor properdin)
Pan paniscus (bonobo/pygmy chimpanzee) : CFP (complement factor properdin)
Canis lupus familiaris (dog) : CFP (complement factor properdin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cfp (complement factor properdin)
Sus scrofa (pig) : CFP (complement factor properdin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,623,282 - 47,630,305 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X47,483,612 - 47,489,704 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X47,368,569 - 47,374,648 (-)NCBINCBI36hg18NCBI36
Build 34X47,239,878 - 47,245,958NCBI
CeleraX51,678,874 - 51,684,967 (-)NCBI
Cytogenetic MapXp11.23NCBI
HuRefX45,196,561 - 45,202,654 (-)NCBIHuRef
CHM1_1X47,514,712 - 47,520,808 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on CFP
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351689
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.