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Gene: THPO (thrombopoietin) Homo sapiens
Symbol: THPO
Name: thrombopoietin
Description: Predicted to have signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; megakaryocyte development; and positive regulation of intracellular signal transduction. Predicted to localize to the extracellular region. Implicated in aplastic anemia; essential thrombocythemia; and thrombocytosis. Biomarker of arteriosclerosis obliterans; essential thrombocythemia; liver cirrhosis; pulmonary hypertension; and toxic shock syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: c-mpl ligand; megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; megakaryocyte stimulating factor; MGC163194; MGDF; MKCSF; ML; MPL ligand; MPLLG; myeloproliferative leukemia virus oncogene ligand; prepro-thrombopoietin; THCYT1; thrombopoietin nirs variant 1; TPO
Mus musculus (house mouse) : Thpo (thrombopoietin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Thpo (thrombopoietin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Thpo (thrombopoietin)
Pan paniscus (bonobo/pygmy chimpanzee) : THPO (thrombopoietin)
Canis lupus familiaris (dog) : THPO (thrombopoietin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Thpo (thrombopoietin)
Sus scrofa (pig) : THPO (thrombopoietin)
Chlorocebus sabaeus (green monkey) : THPO (thrombopoietin)
Heterocephalus glaber (naked mole-rat) : Thpo (thrombopoietin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: TPO (Gene ID: 7173) and THPO (Gene ID: 7066) share the TPO symbol/alias in common. TPO is a widely used alternative name for thrombopoietin (THPO), which can be confused with the official symbol for TPO, thyroid peroxidase. [27 Jun 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl3184,371,935 - 184,381,968 (-)Ensembl
GRCh383184,371,935 - 184,379,688 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373184,089,773 - 184,097,368 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,572,467 - 185,578,626 (-)NCBINCBI36hg18NCBI36
Build 343185,572,474 - 185,578,634NCBI
Celera3182,530,743 - 182,536,902 (-)NCBI
Cytogenetic Map3q27.1NCBI
HuRef3181,496,308 - 181,502,467 (-)NCBIHuRef
CHM1_13184,054,180 - 184,061,933 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on THPO
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351706
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.