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Gene: TNFAIP3 (TNF alpha induced protein 3) Homo sapiens
Symbol: TNFAIP3
Name: TNF alpha induced protein 3
CRRD ID: 1351803
Description: Exhibits several functions, including ubiquitin binding activity; ubiquitin-protein transferase activity; and ubiquitinyl hydrolase activity. Involved in several processes, including negative regulation of macromolecule metabolic process; negative regulation of signal transduction; and protein modification by small protein conjugation or removal. Localizes to nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A20; AISBL; MGC104522; MGC138687; MGC138688; OTU domain-containing protein 7C; OTUD7C; putative DNA-binding protein A20; TNF alpha-induced protein 3; TNFA1P2; TNFAIP3 (A20); tumor necrosis factor alpha-induced protein 3; tumor necrosis factor inducible protein A20; tumor necrosis factor, alpha induced protein 3; tumor necrosis factor, alpha-induced protein 3; zinc finger protein A20
Mus musculus (house mouse) : Tnfaip3 (tumor necrosis factor, alpha-induced protein 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tnfaip3 (TNF alpha induced protein 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tnfaip3 (TNF alpha induced protein 3)
Pan paniscus (bonobo/pygmy chimpanzee) : TNFAIP3 (TNF alpha induced protein 3)
Canis lupus familiaris (dog) : TNFAIP3 (TNF alpha induced protein 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tnfaip3 (TNF alpha induced protein 3)
Sus scrofa (pig) : TNFAIP3 (TNF alpha induced protein 3)
Chlorocebus sabaeus (African green monkey) : TNFAIP3 (TNF alpha induced protein 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl6137,867,214 - 137,883,312 (+)EnsemblGRCh38hg38GRCh38
GRCh386137,866,317 - 137,883,312 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376138,188,325 - 138,204,451 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366138,230,274 - 138,246,142 (+)NCBINCBI36hg18NCBI36
Build 346138,230,273 - 138,246,141NCBI
Celera6138,928,721 - 138,944,581 (+)NCBI
Cytogenetic Map6q23.3NCBI
HuRef6135,750,495 - 135,766,617 (+)NCBIHuRef
CHM1_16138,450,716 - 138,466,833 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TNFAIP3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351803
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.