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Gene: SEC61A1 (SEC61 translocon subunit alpha 1) Homo sapiens
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Symbol: SEC61A1
Name: SEC61 translocon subunit alpha 1
Description: Exhibits calcium channel activity. Involved in SRP-dependent cotranslational protein targeting to membrane; endoplasmic reticulum organization; and posttranslational protein targeting to membrane, translocation. Localizes to endoplasmic reticulum membrane. Implicated in familial juvenile hyperuricemic nephropathy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HNFJ4; HSEC61; protein transport protein SEC61 alpha subunit; protein transport protein Sec61 subunit alpha; protein transport protein Sec61 subunit alpha isoform 1; SEC61; Sec61 alpha 1 subunit; Sec61 alpha-1; sec61 homolog; SEC61 translocon alpha 1 subunit; SEC61A
Orthologs:
Mus musculus (house mouse) : Sec61a1 (Sec61 alpha 1 subunit (S. cerevisiae))  MGI  Alliance
Rattus norvegicus (Norway rat) : Sec61a1 (SEC61 translocon subunit alpha 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sec61a1 (SEC61 translocon alpha 1 subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : SEC61A1 (SEC61 translocon subunit alpha 1)
Canis lupus familiaris (dog) : SEC61A1 (SEC61 translocon subunit alpha 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sec61a1 (SEC61 translocon alpha 1 subunit)
Sus scrofa (pig) : SEC61A1 (SEC61 translocon subunit alpha 1)
Chlorocebus sabaeus (African green monkey) : SEC61A1 (SEC61 translocon subunit alpha 1)
Heterocephalus glaber (naked mole-rat) : Sec61a1 (SEC61 translocon subunit alpha 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3128,051,641 - 128,071,683 (+)EnsemblGRCh38hg38GRCh38
GRCh383128,052,437 - 128,071,683 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373127,770,402 - 127,790,526 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363129,253,902 - 129,273,216 (+)NCBINCBI36hg18NCBI36
Build 343129,253,909 - 129,273,223NCBI
Celera3126,201,130 - 126,220,443 (+)NCBI
Cytogenetic Map3q21.3NCBI
HuRef3125,151,693 - 125,170,962 (+)NCBIHuRef
CHM1_13127,734,421 - 127,753,735 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SEC61A1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351813
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.