IZUMO3 (IZUMO family member 3) - Chinchilla Research Resource Database

Gene: IZUMO3 (IZUMO family member 3) Homo sapiens

Analyze

Symbol:

IZUMO3

Name:

IZUMO family member 3

Description:

Predicted to have protein homodimerization activity. Predicted to localize to the integral component of membrane and plasma membrane; INTERACTS WITH crocidolite asbestos (ortholog).

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

bA20A20.1; C9orf134; chromosome 9 open reading frame 134; izumo sperm-egg fusion protein 3

Orthologs:

Mus musculus (house mouse) : Izumo3 (IZUMO family member 3) MGI Alliance
Rattus norvegicus (Norway rat) : Izumo3 (IZUMO family member 3) Alliance
Chinchilla lanigera (long-tailed chinchilla) : Izumo3 (IZUMO family member 3)
Pan paniscus (bonobo/pygmy chimpanzee) : IZUMO3 (IZUMO family member 3)
Canis lupus familiaris (dog) : IZUMO3 (IZUMO family member 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Izumo3 (IZUMO family member 3)
Sus scrofa (pig) : IZUMO3 (IZUMO family member 3)

more info ...

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Izumo3 (IZUMO family member 3)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Rattus norvegicus (Norway rat):	Izumo3 (IZUMO family member 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Izumo3 (IZUMO family member 3)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	IZUMO3 (IZUMO family member 3)	NCBI	Ortholog
Canis lupus familiaris (dog):	IZUMO3 (IZUMO family member 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Izumo3 (IZUMO family member 3)	NCBI	Ortholog
Sus scrofa (pig):	IZUMO3 (IZUMO family member 3)	HGNC	EggNOG, Ensembl, NCBI, OMA, OrthoDB, Panther, Treefam
Alliance orthologs ³
Mus musculus (house mouse):	Izumo3 (IZUMO family member 3)	Alliance	DIOPT (Ensembl Compara, HGNC, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, Roundup, TreeFam)
Rattus norvegicus (Norway rat):	Izumo3 (IZUMO family member 3)	Alliance	DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	24,542,952 - 24,545,930 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	9	24,543,193 - 24,545,889 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	24,533,227 - 24,536,004 (-)	NCBI	NCBI36		hg18	NCBI36
Celera	9	24,465,817 - 24,468,595 (-)	NCBI
Cytogenetic Map	9	p21.3	NCBI
HuRef	9	24,491,693 - 24,494,156 (-)	NCBI		HuRef
CHM1_1	9	24,543,260 - 24,545,693 (-)	NCBI		CHM1_1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation (Toggle Annotation Detail/Summary View)

Disease Annotations

Gene-Chemical Interaction Annotations

Gene Ontology Annotations

References - uncurated

Genomics

Comparative Map Data

IZUMO3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	24,542,952 - 24,545,930 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	9	24,543,193 - 24,545,889 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	24,533,227 - 24,536,004 (-)	NCBI	NCBI36		hg18	NCBI36
Celera	9	24,465,817 - 24,468,595 (-)	NCBI
Cytogenetic Map	9	p21.3	NCBI
HuRef	9	24,491,693 - 24,494,156 (-)	NCBI		HuRef
CHM1_1	9	24,543,260 - 24,545,693 (-)	NCBI		CHM1_1

Izumo3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm38	4	92,144,318 - 92,147,225 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
MGSCv37	4	91,811,009 - 91,813,912 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	4	91,636,336 - 91,639,239 (-)	NCBI			mm8
Celera	4	90,583,099 - 90,586,002 (-)	NCBI		Celera
Cytogenetic Map	4	C5	NCBI

Izumo3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	5	110,703,837 - 110,706,655 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	110,703,960 - 110,706,656 (-)	Ensembl
Rnor_5.0	5	114,650,553 - 114,653,261 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	112,112,365 - 112,114,591 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	5	105,539,355 - 105,542,173 (-)	NCBI		Celera
Cytogenetic Map	5	q32	NCBI

Izumo3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955472	9,923,831 - 9,958,452 (+)	NCBI	ChiLan1.0	ChiLan1.0

IZUMO3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	9	25,002,186 - 25,004,778 (-)	NCBI	panpan1.1	PanPan1.1
Bonobo Cytomap	9		NCBI

IZUMO3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	43,191,033 - 43,195,120 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog Cytomap	11		NCBI

Izumo3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936611	4,598,387 - 4,600,728 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IZUMO3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	1	198,357,091 - 198,360,043 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	221,066,634 - 221,070,033 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	1		NCBI

miRNA Target Status

Expression

Sequence

Nucleotide Sequences

RefSeq Transcripts	NM_001271706	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001365008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005251333	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006716714	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AL162232	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HY054657	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HY236269	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

NM_001271706 ⟹ NP_001258635

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	9	24,543,215 - 24,545,676 (-)	NCBI
HuRef	9	24,491,693 - 24,494,156 (-)	NCBI
CHM1_1	9	24,543,260 - 24,545,693 (-)	NCBI

Sequence:

show sequence

TGTCGGGGAGCGGGGGTGAAGAAAGAAATGGGTGACCTGTGGTTATTCCTGCTCCTGCCCCTCT
CAGCCTTCCATGGAGTCAAAGGCTGTTTAGAATGTGACCCCAAATTTATAGAGGATGTTGGCTC
CTTGCTGGGAAATCTGATACCTTCAGAAGTCCCCGGCCGAACTCAGCTGCTTGAACGGCAGATT
AAGGAGATGATTCATTTAAGCTTCAAGGTCTCCCACAGTGACAAGAGGCTTCGGGTGTTGGCTG
TTCAGCAGGTTGTTAAGTTGAGAACATGGTTGAAGAATGAATTTTATAAACTGGGCAATGAAAC
ATGGAAAGGTGTCTTTATCTATCAAGGCAAGCTTCTCGATGTCTGCCAAAACCTGGAATCCAAA
CTGAAAGAATTACTAAAGAACTTCTCTGAAATTGTTGTGGTTGAAGGTCCCATTCTTGATTGTT
GGACGTGTCTTCGCATGACTAACAGGTGCTTCAAAGGAGAATATTGTGGAGACGAGGATCCAAG
AAAGGCTGAGAATCGAGAGATTGCTCTATTTCTCATATTGCTGGCAACAGCTGTAATACTGGGA
AGTGCTGTGTTACTATTCCATTTTTGCATCTTTCATCGGAGGAAAATGAAGGCAATACGAAGGT
CGCTAAAGGAATATGTGGAGAAGAAACTTGAAGAATTAATGGGGAAGATAGATGAGAAGGAGGA
GAAAGACTTTAGACTCAGAAAATAAACACATCAACATGG

hide sequence

RefSeq Acc Id:

NM_001365008 ⟹ NP_001351937

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	9	24,542,952 - 24,545,897 (-)	NCBI

RefSeq Acc Id:

XM_005251333 ⟹ XP_005251390

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	9	24,542,974 - 24,545,930 (-)	NCBI

Sequence:

show sequence

CAAGGCTTCTCTATCTCTTGGTGTTCTACACTCAGAACTCAGGTATCCGCTCCCCAGCTGGCAG
TTCCCTCTCCTAGAATGAAGGATAATACTGTTCAGCAGGTTGTTAAGTTGAGAACATGGTTGAA
GAATGAATTTTATAAACTGGGCAATGAAACATGGAAAGGTGTCTTTATCTATCAAGGCAAGCTT
CTCGATGTCTGCCAAAACCTGGAATCCAAACTGAAAGAATTACTAAAGAACTTCTCTGAAATTG
CTTGTTCTGAAGATTGCATTGTGGTTGAAGGTCCCATTCTTGATTGTTGGACGTGTCTTCGCAT
GACTAACAGGTGCTTCAAAGGAGAATATTGTGGAGACGAGGATCCAAGAAAGGCTGAGAATCGA
GAGATTGCTCTATTTCTCATATTGCTGGCAACAGCTGTAATACTGGGAAGTGCTGTGTTACTAT
TCCATTTTTGCATCTTTCATCGGAGGAAAATGAAGGCAATACGAAGGTCGCTAAAGGAATATGT
GGAGAAGAAACTTGAAGAATTAATGGGGAAGATAGATGAGAAGGAGGAGAAAGACTTTAGACTC
AGAAAATAAACACATCAACATGGACAAGAAGTCTTTCATGATTCTCTTAAGTGTTGACTCTAAG
TACAAAACTGGGAGGTAAACCCTTTCTTGGTCATAAAGTCATAGTATTTTAAAACTGAAATAGA
ACTTAGAGTTTCTCTAATGAAAATGCTTATTGATATCCTGAGACAACGGAAGTAATGGGAGAGC
AAATAATTTGGCCAGAGTTGTACAGAAAGTAATGCTGGTATGTTGCAATGCACAGGAAAGATAA
TATGCTGG

hide sequence

RefSeq Acc Id:

XM_006716714 ⟹ XP_006716777

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	9	24,544,201 - 24,545,884 (-)	NCBI

Sequence:

show sequence

CCGCTCCCCAGCTGGCAGTTCCCTCTCCTAGAATGAAGGATAATAGTCAGTAAACAACTAAAGA
TCATTAAACTAAACAACTAAAGATTGCCCGATAGTGGGATGGAAACAGCGGGAAAAGTGGAGTC
AGACTATCCAGAACCAGGCTCTCATTCCCGGATTTTTGAAGGAAAAGGAACTAAGTGAACTAGT
TGCCAGGACAACCTGCTGTCGGGGAGCGGGGGTGAAGAAAGAAATGGGTGACCTGTGGTTATTC
CTGCTCCTGCCCCTCTCAGCCTTCCATGGAGTCAAAGGCTGTTTAGAATGTGACCCCAAATTTA
TAGAGGATGTTGGCTCCTTGCTGGGAAATCTGATACCTTCAGAAGTCCCCGGCCGAACTCAGCT
GCTTGAACGGCAGATTAAGGAGATGATTCATTTAAGCTTCAAGGTCTCCCACAGTGACAAGAGG
CTTCGGGTGTTGGCTGTTCAGCAGGTTGTTAAGTTGAGAACATGGTTGAAGAATGAATTTTATA
AACTGGGCAATGAAACATGGAAAGGTGTCTTTATCTATCAAGGCAAGCTTCTCGATGTCTGCCA
AAACCTGGAATCCAAACTGAAAGAATTACTAAAGAACTTCTCTGAAATTGCTTGTTCTGAAGAT
TGCAGTGAGTACAGTACATGTGACGCCTTGAGTTGTGGTTGAAGGTCCCATTCTTGATTGTTGG
ACGTGTCTTCGCATGACTAACAGGTGCTTCAAAGGAGAATATTGTGGAG

hide sequence

Protein Sequences

Protein RefSeqs	NP_001258635	(Get FASTA)	NCBI Sequence Viewer
	NP_001351937	(Get FASTA)	NCBI Sequence Viewer
	XP_005251390	(Get FASTA)	NCBI Sequence Viewer
	XP_006716777	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	Q5VZ72	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001258635 ⟸ NM_001271706
- Peptide Label:	isoform 1 precursor
- UniProtKB:	S4R3E6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGDLWLFLLLPLSAFHGVKGCLECDPKFIEDVGSLLGNLIPSEVPGRTQLLERQIKEMIHLSFK VSHSDKRLRVLAVQQVVKLRTWLKNEFYKLGNETWKGVFIYQGKLLDVCQNLESKLKELLKNFS EIVVVEGPILDCWTCLRMTNRCFKGEYCGDEDPRKAENREIALFLILLATAVILGSAVLLFHFC IFHRRKMKAIRRSLKEYVEKKLEELMGKIDEKEEKDFRLRK hide sequence

RefSeq Acc Id:	XP_005251390 ⟸ XM_005251333
- Peptide Label:	isoform X2
- Sequence:	show sequence MKDNTVQQVVKLRTWLKNEFYKLGNETWKGVFIYQGKLLDVCQNLESKLKELLKNFSEIACSED CIVVEGPILDCWTCLRMTNRCFKGEYCGDEDPRKAENREIALFLILLATAVILGSAVLLFHFCI FHRRKMKAIRRSLKEYVEKKLEELMGKIDEKEEKDFRLRK hide sequence

RefSeq Acc Id:	XP_006716777 ⟸ XM_006716714
- Peptide Label:	isoform X3
- Sequence:	show sequence MGDLWLFLLLPLSAFHGVKGCLECDPKFIEDVGSLLGNLIPSEVPGRTQLLERQIKEMIHLSFK VSHSDKRLRVLAVQQVVKLRTWLKNEFYKLGNETWKGVFIYQGKLLDVCQNLESKLKELLKNFS EIACSEDCSEYSTCDALSCG hide sequence

RefSeq Acc Id:	NP_001351937 ⟸ NM_001365008
- Peptide Label:	isoform 2 precursor

Clinical Variants

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:31421	AgrOrtholog
COSMIC	IZUMO3	COSMIC
Ensembl Genes	ENSG00000205442	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSP00000391107	UniProtKB/TrEMBL
	ENSP00000438895	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSP00000474246	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENST00000418122	UniProtKB/TrEMBL
	ENST00000543880	ENTREZGENE, UniProtKB/Swiss-Prot
	ENST00000604921	ENTREZGENE, UniProtKB/TrEMBL
GTEx	ENSG00000205442	GTEx
HGNC ID	HGNC:31421	ENTREZGENE
Human Proteome Map	IZUMO3	Human Proteome Map
InterPro	IZUMO	UniProtKB/Swiss-Prot
KEGG Report	hsa:100129669	UniProtKB/TrEMBL
NCBI Gene	100129669	ENTREZGENE
Pfam	IZUMO	UniProtKB/Swiss-Prot
PharmGKB	PA165585816	PharmGKB
UniGene	Hs.573530	ENTREZGENE
UniProt	H7BZS5_HUMAN	UniProtKB/TrEMBL
	IZUM3_HUMAN	UniProtKB/Swiss-Prot, ENTREZGENE
	S4R3E6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

More on IZUMO3
	Alliance Gene
	NCBI Gene
	Ensembl Gene
	JBrowse: hg19 hg38
	HGNC Report
	NCBI Genome Data Viewer

CRRD Object Information
CRRD ID:	1351856
Created:	2005-03-08
Species:	Homo sapiens
Last Modified:	2019-11-26
Status:	ACTIVE

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Annotations - ClinVar