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Gene: APLN (apelin) Homo sapiens
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Symbol: APLN
Name: apelin
Description: This gene encodes a peptide that functions as an endogenous ligand for the G-protein coupled apelin receptor. The encoded preproprotein is proteolytically processed into biologically active C-terminal peptide fragments. These peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. [provided by RefSeq, Feb 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AGTRL1 ligand; APEL; APJ endogenous ligand; XNPEP2
Orthologs:
Mus musculus (house mouse) : Apln (apelin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Apln (apelin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apln (apelin)
Pan paniscus (bonobo/pygmy chimpanzee) : APLN (apelin)
Canis lupus familiaris (dog) : APLN (apelin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apln (apelin)
Sus scrofa (pig) : APLN (apelin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X129,645,259 - 129,654,956 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X128,779,236 - 128,788,933 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X128,607,006 - 128,616,595 (-)NCBINCBI36hg18NCBI36
Build 34X128,504,860 - 128,514,449NCBI
CeleraX129,165,798 - 129,175,495 (-)NCBI
Cytogenetic MapXq26.1NCBI
HuRefX118,183,705 - 118,187,243 (-)NCBIHuRef
CHM1_1X128,690,603 - 128,700,300 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on APLN
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1351986
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.