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Gene: ITGAL (integrin subunit alpha L) Homo sapiens
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Symbol: ITGAL
Name: integrin subunit alpha L
Description: Exhibits ICAM-3 receptor activity and cell adhesion molecule binding activity. Involved in several processes, including T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and memory T cell extravasation. Localizes to the cell surface and integrin alphaL-beta2 complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: antigen CD11A (p180); antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide; CD11 antigen-like family member A; CD11A; integrin alpha L; integrin alpha-L; integrin gene promoter; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide); leukocyte adhesion glycoprotein LFA-1 alpha chain; leukocyte function-associated molecule 1 alpha chain; LFA-1; LFA-1 alpha; LFA-1A; LFA1A; lymphocyte function-associated antigen 1; lymphocyte function-associated antigen 1, alpha polypeptide
Orthologs:
Mus musculus (house mouse) : Itgal (integrin alpha L)  MGI  Alliance
Rattus norvegicus (Norway rat) : Itgal (integrin subunit alpha L)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itgal (integrin subunit alpha L)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGAL (integrin subunit alpha L)
Canis lupus familiaris (dog) : ITGAL (integrin subunit alpha L)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itgal (integrin subunit alpha L)
Sus scrofa (pig) : ITGAL (integrin subunit alpha L)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1630,472,719 - 30,523,185 (+)Ensembl
GRCh381630,472,683 - 30,523,185 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371630,483,983 - 30,534,506 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,391,572 - 30,442,007 (+)NCBINCBI36hg18NCBI36
Build 341630,391,571 - 30,442,006NCBI
Celera1629,763,904 - 29,814,478 (-)NCBI
Cytogenetic Map16p11.2NCBI
HuRef1628,046,747 - 28,097,233 (+)NCBIHuRef
CHM1_11631,801,165 - 31,851,694 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ITGAL
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1352170
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.