Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: MIR133B (microRNA 133b) Homo sapiens
Analyze
Symbol: MIR133B
Name: microRNA 133b
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The encoded miRNA is considered a canonical myomiR and is important for normal cardiac and skeletal muscle development. It is additionally important for normal development in non-muscle tissues, and is abnormally expressed in a variety of cancers. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2017]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-133b; MIRN133B; miRNA133B
Orthologs:
Mus musculus (house mouse) : Mir133b (microRNA 133b)  MGI
Rattus norvegicus (Norway rat) : Mir133b (microRNA 133b)  Alliance
Sus scrofa (pig) : MIR133B (microRNA mir-133b)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,148,923 - 52,149,041 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37652,013,721 - 52,013,839 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,121,679 - 52,121,797 (+)NCBINCBI36hg18NCBI36
Celera653,674,858 - 53,674,976 (+)NCBI
Cytogenetic Map6p12.2NCBI
HuRef651,844,715 - 51,844,833 (+)NCBIHuRef
CHM1_1652,015,930 - 52,016,048 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References - curated
References - uncurated

Genomics

Comparative Map Data
miRNA Target Status

Sequence

Nucleotide Sequences
Clinical Variants

Additional Information

External Database Links
 
More on MIR133B
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1352188
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.