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Gene: IRS4 (insulin receptor substrate 4) Homo sapiens
Symbol: IRS4
Name: insulin receptor substrate 4
Description: IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 160 kDa phosphotyrosine protein; IRS-4; phosphoprotein of 160 kDa; pp160; PY160
Mus musculus (house mouse) : Irs4 (insulin receptor substrate 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Irs4 (insulin receptor substrate 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irs4 (insulin receptor substrate 4)
Pan paniscus (bonobo/pygmy chimpanzee) : IRS4 (insulin receptor substrate 4)
Canis lupus familiaris (dog) : IRS4 (insulin receptor substrate 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irs4 (insulin receptor substrate 4)
Sus scrofa (pig) : IRS4 (insulin receptor substrate 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X108,719,949 - 108,736,584 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X107,963,179 - 107,979,643 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X107,862,368 - 107,866,307 (-)NCBINCBI36hg18NCBI36
Build 34X107,781,856 - 107,785,784NCBI
CeleraX108,447,146 - 108,451,026 (-)NCBI
Cytogenetic MapXq22.3NCBI
HuRefX97,599,533 - 97,603,519 (-)NCBIHuRef
CHM1_1X107,886,615 - 107,890,495 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on IRS4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1352224
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.