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Gene: MACF1 (microtubule actin crosslinking factor 1) Homo sapiens
Symbol: MACF1
Name: microtubule actin crosslinking factor 1
Description: Exhibits actin filament binding activity and microtubule minus-end binding activity. Involved in several processes, including Golgi to plasma membrane protein transport; positive regulation of axon extension; and regulation of focal adhesion assembly. Localizes to several cellular components, including the Golgi apparatus; cytoskeleton; and ruffle membrane. Predicted to colocalize with the intermediate filament. Implicated in lissencephaly.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 620 kDa actin binding protein; ABP620; ACF7; actin cross-linking family protein 7; FLJ45612; FLJ46776; KIAA0465; KIAA1251; LIS9; MACF; macrophin 1; macrophin 1 isoform; microtubule-actin cross-linking factor 1; microtubule-actin crosslinking factor 1; OFC4; trabeculin-alpha
Mus musculus (house mouse) : Macf1 (microtubule-actin crosslinking factor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Macf1 (microtubule-actin crosslinking factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Macf1 (microtubule actin crosslinking factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MACF1 (microtubule actin crosslinking factor 1)
Canis lupus familiaris (dog) : MACF1 (microtubule actin crosslinking factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Macf1 (microtubule actin crosslinking factor 1)
Sus scrofa (pig) : MACF1 (microtubule actin crosslinking factor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38139,084,167 - 39,487,138 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37139,549,839 - 39,952,810 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36139,319,705 - 39,725,376 (+)NCBINCBI36hg18NCBI36
Build 34139,465,902 - 39,621,882NCBI
Celera137,828,167 - 38,234,164 (+)NCBI
Cytogenetic Map1p34.3NCBI
HuRef137,669,045 - 38,071,866 (+)NCBIHuRef
CHM1_1139,665,458 - 40,068,698 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on MACF1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1352225
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.