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Gene: CLDN2 (claudin 2) Homo sapiens
Symbol: CLDN2
Name: claudin 2
Description: This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: claudin-2; SP82
Mus musculus (house mouse) : Cldn2 (claudin 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cldn2 (claudin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cldn2 (claudin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CLDN2 (claudin 2)
Canis lupus familiaris (dog) : CLDN2 (claudin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cldn2 (claudin 2)
Sus scrofa (pig) : CLDN2 (claudin 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X106,900,164 - 106,930,861 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X106,143,394 - 106,174,091 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X106,050,290 - 106,060,747 (+)NCBINCBI36hg18NCBI36
Build 34X105,969,778 - 105,980,236NCBI
CeleraX106,614,779 - 106,645,477 (+)NCBI
Cytogenetic MapXq22.3NCBI
HuRefX95,771,755 - 95,802,061 (+)NCBIHuRef
CHM1_1X106,054,200 - 106,084,897 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CLDN2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1352349
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.