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Gene: CCNB3 (cyclin B3) Homo sapiens
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Symbol: CCNB3
Name: cyclin B3
Description: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the interphase nucleus. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: G2/mitotic-specific cyclin-B3
Orthologs:
Mus musculus (house mouse) : Ccnb3 (cyclin B3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ccnb3 (cyclin B3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ccnb3 (cyclin B3)
Pan paniscus (bonobo/pygmy chimpanzee) : CCNB3 (cyclin B3)
Canis lupus familiaris (dog) : CCNB3 (cyclin B3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ccnb3 (cyclin B3)
Sus scrofa (pig) : CCNB3 (cyclin B3)
more info ...
Related Pseudogenes: CCNB3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X50,202,713 - 50,351,914 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X50,027,540 - 50,094,913 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X50,044,280 - 50,111,653 (+)NCBINCBI36hg18NCBI36
Build 34X49,860,575 - 49,927,945NCBI
CeleraX54,071,225 - 54,138,495 (+)NCBI
Cytogenetic MapXp11.22NCBI
HuRefX47,471,841 - 47,539,060 (+)NCBIHuRef
CHM1_1X50,107,188 - 50,174,744 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
 
More on CCNB3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1352366
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.