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Gene: ALOX15 (arachidonate 15-lipoxygenase) Homo sapiens
Symbol: ALOX15
Name: arachidonate 15-lipoxygenase
CRRD ID: 1352372
Description: Exhibits oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including cellular response to interleukin-13; fatty acid metabolic process; and positive regulation of ERK1 and ERK2 cascade. Localizes to cytosol; extrinsic component of cytoplasmic side of plasma membrane; and lipid droplet. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 12-LOX; 12/15-lipoxygenase; 15-lipooxygenase-1; 15-lipoxygenase type 1; 15-LOX; 15-LOX type 1; 15-LOX-1; 15-LOX2; 15LOX-1; arachidonate 12-lipoxygenase, leukocyte-type; arachidonate omega-6 lipoxygenase; hepoxilin A3 synthase Alox15; linoleate 13S-lipoxygenase; LOG15; polyunsaturated fatty acid lipoxygenase ALOX15
Mus musculus (house mouse) : Alox15 (arachidonate 15-lipoxygenase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Alox15 (arachidonate 15-lipoxygenase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Alox15 (arachidonate 15-lipoxygenase)
Pan paniscus (bonobo/pygmy chimpanzee) : ALOX15 (arachidonate 15-lipoxygenase)
Canis lupus familiaris (dog) : ALOX15 (arachidonate 15-lipoxygenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alox15 (arachidonate 15-lipoxygenase)
Sus scrofa (pig) : ALOX15 (arachidonate 15-lipoxygenase)
Chlorocebus sabaeus (African green monkey) : ALOX15 (arachidonate 15-lipoxygenase)
more info ...
Related Pseudogenes: ALOX15P1   ALOX15P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl174,630,919 - 4,642,294 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl174,630,902 - 4,642,294 (-)EnsemblGRCh38hg38GRCh38
GRCh38174,630,919 - 4,641,678 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37174,534,214 - 4,545,583 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,480,963 - 4,491,709 (-)NCBINCBI36hg18NCBI36
Build 34174,480,964 - 4,491,709NCBI
Celera174,546,922 - 4,554,338 (-)NCBI
Cytogenetic Map17p13.2NCBI
HuRef174,423,571 - 4,434,147 (-)NCBIHuRef
CHM1_1174,542,997 - 4,553,746 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on ALOX15
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1352372
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.