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Gene: BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex) Homo sapiens
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Symbol: BRK1
Name: BRICK1 subunit of SCAR/WAVE actin nucleating complex
Description: Exhibits identical protein binding activity. Contributes to Rac GTPase binding activity. Involved in Rac protein signal transduction; positive regulation of cellular component organization; and protein homotrimerization. Localizes to the SCAR complex; PARTICIPATES IN platelet-derived growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2-hydroxypropanoic acid; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BRICK1, SCAR/WAVE actin nucleating complex subunit; BRICK1, SCAR/WAVE actin-nucleating complex subunit; BRICK1, SCAR/WAVE actin-nucleating complex subunit, homolog; Brk1-like; C3orf10; haematopoietic stem/progenitor cell protein 300; hHBrk1; HSPC300; MDS027; probable protein BRICK1; protein BRICK1
Orthologs:
Related Pseudogenes: BRK1P1   BRK1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl310,115,675 - 10,127,190 (+)Ensembl
GRCh38310,115,675 - 10,127,190 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37310,157,333 - 10,168,874 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36310,132,333 - 10,143,874 (+)NCBINCBI36hg18NCBI36
Build 34310,132,332 - 10,143,873NCBI
Celera310,093,000 - 10,104,540 (+)NCBI
Cytogenetic Map3p25.3NCBI
CHM1_1310,107,444 - 10,118,867 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - uncurated

Genomics

Comparative Map Data
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miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on BRK1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1352437
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.