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Gene: NR1H2 (nuclear receptor subfamily 1 group H member 2) Homo sapiens
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Symbol: NR1H2
Name: nuclear receptor subfamily 1 group H member 2
Description: Exhibits several functions, including ATPase binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and apolipoprotein A-I receptor binding activity. Involved in several processes, including negative regulation of lipid localization; positive regulation of cellular metabolic process; and positive regulation of cholesterol efflux. Localizes to the cytoplasm and nucleus. Implicated in obesity and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLJ17564; liver X nuclear receptor beta; liver X receptor beta; liver X receptor-beta; LX receptor beta; LXR-b; LXRB; NER; NER-I; nuclear orphan receptor LXR-beta; nuclear receptor NER; nuclear receptor subfamily 1, group H, member 2; oxysterols receptor LXR-beta; RIP15; steroid hormone-nuclear receptor NER; ubiquitously-expressed nuclear receptor; UNR
Orthologs:
Mus musculus (house mouse) : Nr1h2 (nuclear receptor subfamily 1, group H, member 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nr1h2 (nuclear receptor subfamily 1, group H, member 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nr1h2 (nuclear receptor subfamily 1 group H member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NR1H2 (nuclear receptor subfamily 1 group H member 2)
Canis lupus familiaris (dog) : NR1H2 (nuclear receptor subfamily 1 group H member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr1h2 (nuclear receptor subfamily 1 group H member 2)
Sus scrofa (pig) : NR1H2 (nuclear receptor subfamily 1 group H member 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381950,376,457 - 50,383,388 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371950,879,680 - 50,886,285 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361955,571,497 - 55,578,079 (+)NCBINCBI36hg18NCBI36
Build 341955,571,514 - 55,578,048NCBI
Celera1947,929,924 - 47,936,510 (+)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1947,217,814 - 47,224,423 (+)NCBIHuRef
CHM1_11950,881,453 - 50,888,062 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on NR1H2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1352469
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.