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Gene: CDC45 (cell division cycle 45) Homo sapiens
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Symbol: CDC45
Name: cell division cycle 45
Description: Predicted to have 3'-5' DNA helicase activity; DNA binding activity; and chromatin binding activity. Predicted to be involved in several processes, including DNA-dependent DNA replication; double-strand break repair via break-induced replication; and positive regulation of G1/S transition of mitotic cell cycle. Localizes to the centrosome and nucleoplasm. Implicated in Meier-Gorlin syndrome 7.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDC45 (cell division cycle 45, S.cerevisiae, homolog)-like; CDC45 cell division cycle 45 homolog; CDC45 cell division cycle 45-like; CDC45-related protein; CDC45L; CDC45L2; cell division control protein 45 homolog; cell division cycle 45 homolog; cell division cycle 45-like 2; human CDC45; MGORS7; PORC-PI-1
Orthologs:
Mus musculus (house mouse) : Cdc45 (cell division cycle 45)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cdc45 (cell division cycle 45)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdc45 (cell division cycle 45)
Pan paniscus (bonobo/pygmy chimpanzee) : CDC45 (cell division cycle 45)
Canis lupus familiaris (dog) : CDC45 (cell division cycle 45)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdc45 (cell division cycle 45)
Sus scrofa (pig) : CDC45 (cell division cycle 45)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,479,294 - 19,520,612 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372219,466,984 - 19,508,135 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362217,847,416 - 17,888,135 (+)NCBINCBI36hg18NCBI36
Build 342217,841,969 - 17,882,688NCBI
Celera223,319,674 - 3,360,395 (+)NCBI
Cytogenetic Map22q11.21NCBI
HuRef223,088,162 - 3,128,966 (+)NCBIHuRef
CHM1_12219,466,920 - 19,507,702 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CDC45
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1352573
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.