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Gene: ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group)) Homo sapiens
Symbol: ABCG2
Name: ATP binding cassette subfamily G member 2 (Junior blood group)
Description: Exhibits protein homodimerization activity and transmembrane transporter activity. Involved in several processes, including riboflavin transport; urate salt excretion; and xenobiotic transport across blood-brain barrier. Localizes to several cellular components, including the brush border membrane; cell surface; and membrane raft. Implicated in gout; hematologic cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Biomarker of acute myeloid leukemia; breast carcinoma; megakaryocytic leukemia; multiple myeloma; and precursor lymphoblastic lymphoma/leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ABC transporter; ABC15; ABCP; ATP-binding cassette sub-family G member 2; ATP-binding cassette transporter G2; ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group); BCRP; BCRP1; BMDP; breast cancer resistance protein; broad substrate specificity ATP-binding cassette transporter ABCG2; CD338; CDw338; EST157481; gout susceptibility 1; GOUT1; MGC102821; mitoxantrone resistance protein; mitoxantrone resistance-associated protein; MRX; multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2; MXR; MXR-1; MXR1; placenta specific MDR protein; placenta-specific ATP-binding cassette transporter; UAQTL1; urate exporter
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38488,090,264 - 88,231,626 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37489,011,416 - 89,152,569 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36489,230,440 - 89,299,035 (-)NCBINCBI36hg18NCBI36
Build 34489,370,018 - 89,436,901NCBI
Celera486,303,350 - 86,371,627 (-)NCBI
Cytogenetic Map4q22.1NCBI
HuRef484,757,887 - 84,903,974 (-)NCBIHuRef
CHM1_1488,988,243 - 89,128,985 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ABCG2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1352615
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.