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Gene: ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group)) Homo sapiens
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Symbol: ABCG2
Name: ATP binding cassette subfamily G member 2 (Junior blood group)
Description: Exhibits protein homodimerization activity and transmembrane transporter activity. Involved in several processes, including riboflavin transport; urate salt excretion; and xenobiotic transport across blood-brain barrier. Localizes to several cellular components, including the brush border membrane; cell surface; and membrane raft. Implicated in gout; hematologic cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Biomarker of acute myeloid leukemia; breast carcinoma; megakaryocytic leukemia; multiple myeloma; and precursor lymphoblastic lymphoma/leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ABC transporter; ABC15; ABCP; ATP-binding cassette sub-family G member 2; ATP-binding cassette transporter G2; ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group); BCRP; BCRP1; BMDP; breast cancer resistance protein; broad substrate specificity ATP-binding cassette transporter ABCG2; CD338; CDw338; EST157481; gout susceptibility 1; GOUT1; MGC102821; mitoxantrone resistance protein; mitoxantrone resistance-associated protein; MRX; multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2; MXR; MXR-1; MXR1; placenta specific MDR protein; placenta-specific ATP-binding cassette transporter; UAQTL1; urate exporter
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38488,090,264 - 88,231,626 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37489,011,416 - 89,152,569 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36489,230,440 - 89,299,035 (-)NCBINCBI36hg18NCBI36
Build 34489,370,018 - 89,436,901NCBI
Celera486,303,350 - 86,371,627 (-)NCBI
Cytogenetic Map4q22.1NCBI
HuRef484,757,887 - 84,903,974 (-)NCBIHuRef
CHM1_1488,988,243 - 89,128,985 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ABCG2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1352615
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.