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Gene: PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) Homo sapiens
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Symbol: PIK3CA
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Description: Exhibits 1-phosphatidylinositol-3-kinase activity. Involved in negative regulation of anoikis and phosphorylation. Localizes to the phosphatidylinositol 3-kinase complex, class IA. Implicated in several diseases, including CLOVES syndrome; Cowden syndrome; breast cancer (multiple); carcinoma (multiple); and epidermal nevus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CLAPO; CLOVE; CWS5; MCAP; MCM; MCMTC; MGC142161; MGC142163; p110-alpha; p110alpha; phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; phosphoinositide-3-kinase catalytic alpha polypeptide; phosphoinositide-3-kinase, catalytic, alpha polypeptide; PI3-kinase p110 subunit alpha; PI3-kinase subunit alpha; PI3K; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase p110; ptdIns-3-kinase subunit alpha; ptdIns-3-kinase subunit p110-alpha; serine/threonine protein kinase PIK3CA
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl3179,148,114 - 179,240,093 (+)Ensembl
GRCh383179,148,114 - 179,240,093 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373178,866,311 - 178,952,500 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363180,349,005 - 180,435,194 (+)NCBINCBI36hg18NCBI36
Build 343180,349,012 - 180,435,197NCBI
Celera3177,295,797 - 177,383,366 (+)NCBI
Cytogenetic Map3q26.32NCBI
HuRef3176,269,843 - 176,355,772 (+)NCBIHuRef
CHM1_13178,829,221 - 178,920,795 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations