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Gene: PKN1 (protein kinase N1) Homo sapiens
Symbol: PKN1
Name: protein kinase N1
Description: Exhibits several functions, including androgen receptor binding activity; enzyme binding activity; and histone kinase activity (H3-T11 specific). Involved in several processes, including epithelial cell migration; histone H3-T11 phosphorylation; and regulation of transcription by RNA polymerase II. Localizes to several cellular components, including cleavage furrow; endosome; and midbody.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DBK; MGC46204; PAK-1; PAK1; PKN; PKN-ALPHA; PRK1; PRKCL1; protease-activated kinase 1; protein kinase C-like 1; protein kinase C-like PKN; protein kinase C-related kinase 1; protein kinase PKN-alpha; protein-kinase C-related kinase 1; serine-threonine kinase N; serine-threonine protein kinase N; serine/threonine protein kinase N; serine/threonine-protein kinase N1
Mus musculus (house mouse) : Pkn1 (protein kinase N1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pkn1 (protein kinase N1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pkn1 (protein kinase N1)
Pan paniscus (bonobo/pygmy chimpanzee) : PKN1 (protein kinase N1)
Canis lupus familiaris (dog) : PKN1 (protein kinase N1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pkn1 (protein kinase N1)
Sus scrofa (pig) : PKN1 (protein kinase N1)
Chlorocebus sabaeus (African green monkey) : PKN1 (protein kinase N1)
Heterocephalus glaber (naked mole-rat) : Pkn1 (protein kinase N1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1914,433,053 - 14,471,867 (+)EnsemblGRCh38hg38GRCh38
GRCh381914,433,306 - 14,471,859 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371914,544,166 - 14,582,679 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,405,166 - 14,443,679 (+)NCBINCBI36hg18NCBI36
Build 341914,405,165 - 14,443,678NCBI
Celera1914,438,283 - 14,476,800 (+)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1914,121,160 - 14,152,794 (+)NCBIHuRef
CHM1_11914,544,156 - 14,582,658 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on PKN1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1352784
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.