Gene: HLA-B (major histocompatibility complex, class I, B) Homo sapiens
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Symbol: HLA-B
Name: major histocompatibility complex, class I, B
Description: HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ankylosing spondylitis; AS; b'DT; B-4901; B-5001; bw-22; bw-4; bw-41; bw-44; Bw-45; bw-46; Bw-47; Bw-48; Bw-50; bw-52; bw-53; bw-54; bw-55; Bw-56; bw-57; Bw-58; bw-60; class I MHC, HLA-B antigen; epididymis secretory protein Li 83; HEL-S-83; histocompatibility antigen; HLA -B; HLA B-40011; HLA B44; HLA class I antigen HLA-B; HLA class I histocompatibility antigen, B alpha chain; HLA class I histocompatibility antigen, B-12 alpha chain; HLA class I histocompatibility antigen, B-21 alpha chain; HLA class I histocompatibility antigen, B-45 alpha chain; HLA class I histocompatibility antigen, B-47 alpha chain; HLA class I histocompatibility antigen, B-48 alpha chain; HLA class I histocompatibility antigen, B-5 alpha chain; HLA class I histocompatibility antigen, B-50 alpha chain; HLA class I histocompatibility antigen, B-56 alpha chain; HLA class I histocompatibility antigen, B-59 alpha chain; HLA class I histocompatibility antigen, B-67 alpha chain; HLA class I histocompatibility antigen, B-7 alpha chain; HLA class I histocompatibility antigen, B-73 alpha chain; HLA class I histocompatibility antigen, B-8 alpha chain; HLA class I histocompatibility antigen, B-82 alpha chain; HLA class I histocompatibility antigen, Cw-5 alpha chain; HLA locus; HLA molecule; HLA-B alpha chain; HLA-B alpha chain (B*2706); HLA-B alpha chain (B*5002); HLA-B alpha chain (HLA-B*7301); HLA-B alpha-chain; HLA-B*45ZJ; HLA-B*5901 antigen; HLA-B-3506; HLA-B-3905; HLA-B-5502; HLA-B-5601; HLA-B-5602; HLA-B-6701; HLA-B-7301; HLA-B15; HLA-B27; HLA-B35; HLA-B35 antigen; HLA-B39; HLA-B49; HLA-B50; HLA-B55; HLA-B59; HLA-B61; HLA-B73; HLA-Bw45 antigen; HLA-Bw50 antigen; HLA-C; HLA-Cw; HLA-DRB1; HLAB; HLAC; lecocyte antigen B; Leukocyte Antigen; leukocyte antigen class I-B; Leukoocyte Antigen; lymphocyte antigen; major histocompatability complex B antigen; MGC111087; MHC antigen; MHC class 1 antigen; MHC class I alpha chain; MHC class I anitgen; MHC class I antigen B*13; MHC class I antigen B*14; MHC class I antigen B*15; MHC class I antigen B*18; MHC class I antigen B*27; MHC class I antigen B*35; MHC class I antigen B*37; MHC class I antigen B*38; MHC class I antigen B*39; MHC class I antigen B*40; MHC class I antigen B*41; MHC class I antigen B*42; MHC class I antigen B*44; MHC class I antigen B*45; MHC class I antigen B*46; MHC class I antigen B*47; MHC class I antigen B*48; MHC class I antigen B*49; MHC class I antigen B*50; MHC class I antigen B*51; MHC class I antigen B*52; MHC class I antigen B*53; MHC class I antigen B*54; MHC class I antigen B*55; MHC class I antigen B*56; MHC class I antigen B*57; MHC class I antigen B*58; MHC class I antigen B*59; MHC class I antigen B*67; MHC class I antigen B*7; MHC class I antigen B*73; MHC class I antigen B*78; MHC class I antigen B*8; MHC class I antigen B*81; MHC class I antigen B*82; MHC class I antigen Cw*5; MHC class I antigen GN00104; MHC class I antigen HLA-B alpha chain; MHC class I antigen HLA-B heavy chain; MHC class I antigen SHCHA; MHC class I antigene; MHC Class I HLA heavy chain; MHC class I human leukocyte antigen; MHC class I molecule; MHC class II antigen; MHC class l antigen; MHC classI antigen; MHC HLA-B cell surface glycoprotein; MHC HLA-B transmembrane glycoprotein; MHC HLA-B27-HS; MHC HLA-B27d; MHC HLA-B39N; SPDA1; truncated class I antigen; truncated MHC class I antigen
Orthologs:
Mus musculus (house mouse) : H2-M2 (histocompatibility 2, M region locus 2)  MGI  Alliance
Canis lupus familiaris (dog) : DLA-64 (MHC class I DLA-64)
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Related Pseudogenes: HLA-T  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,353,866 - 31,357,245 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,321,649 - 31,324,989 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,429,628 - 31,432,914 (-)NCBINCBI36hg18NCBI36
Build 34631,429,629 - 31,432,914NCBI
Celera632,921,554 - 32,924,897 (-)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,112,051 - 31,115,393 (-)NCBIHuRef
CHM1_1631,323,551 - 31,326,953 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Sequence

Nucleotide Sequences