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Gene: DDX3X (DEAD-box helicase 3 X-linked) Homo sapiens
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Symbol: DDX3X
Name: DEAD-box helicase 3 X-linked
Description: The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATP-dependent RNA helicase DDX3X; CAP-Rf; DBX; DDX14; DDX3; DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; DEAD box protein 3, X-chromosomal; DEAD box, X isoform; DEAD-box helicase 3, X-linked; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3; DEAD/H box-3; helicase like protein 2; helicase-like protein 2; HLP2; MRX102
Orthologs:
Mus musculus (house mouse) : Ddx3x (DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ddx3x (DEAD-box helicase 3, X-linked)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ddx3x (DEAD-box helicase 3 X-linked)
Pan paniscus (bonobo/pygmy chimpanzee) : DDX3X (DEAD-box helicase 3, X-linked)
Canis lupus familiaris (dog) : DDX3X (DEAD-box helicase 3 X-linked)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ddx3x (DEAD-box helicase 3 X-linked)
Sus scrofa (pig) : DDX3X (DEAD-box helicase 3 X-linked)
more info ...
Related Pseudogenes: DDX3P3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X41,333,308 - 41,364,472 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X41,192,561 - 41,209,527 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X41,077,595 - 41,094,471 (+)NCBINCBI36hg18NCBI36
Build 34X40,948,904 - 40,979,978NCBI
CeleraX45,333,407 - 45,350,283 (+)NCBI
Cytogenetic MapXp11.4NCBI
HuRefX38,924,970 - 38,941,587 (+)NCBIHuRef
CHM1_1X41,225,277 - 41,256,447 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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References - uncurated

Genomics

Comparative Map Data
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Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on DDX3X
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1352934
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.