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Gene: DDT (D-dopachrome tautomerase) Homo sapiens
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Symbol: DDT
Name: D-dopachrome tautomerase
Description: Exhibits cytokine receptor binding activity and phenylpyruvate tautomerase activity. Involved in negative regulation of macrophage chemotaxis; positive regulation of ERK1 and ERK2 cascade; and positive regulation of tumor necrosis factor production. Localizes to the extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: D-dopachrome decarboxylase; D-DT; DDCT; FLJ78842; MIF-2; MIF2; phenylpyruvate tautomerase II
Orthologs:
Mus musculus (house mouse) : Ddt (D-dopachrome tautomerase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ddt (D-dopachrome tautomerase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ddt (D-dopachrome tautomerase)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100991346 (D-dopachrome decarboxylase)
Canis lupus familiaris (dog) : DDT (D-dopachrome tautomerase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101963449 (D-dopachrome decarboxylase)
Sus scrofa (pig) : DDT (D-dopachrome tautomerase)
Chlorocebus sabaeus (African green monkey) : DDT (D-dopachrome tautomerase)
Heterocephalus glaber (naked mole-rat) : Ddt (D-dopachrome tautomerase)
more info ...
Related Pseudogenes: DDTP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2223,971,365 - 23,979,828 (-)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl2223,971,378 - 23,980,469 (-)EnsemblGRCh38hg38GRCh38
GRCh382223,971,365 - 23,979,828 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372224,313,554 - 24,322,019 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,643,554 - 22,652,019 (-)NCBINCBI36hg18NCBI36
Build 342222,638,114 - 22,646,573NCBI
Celera228,114,132 - 8,122,585 (-)NCBI
Cytogenetic Map22q11.23NCBI
HuRef227,261,709 - 7,270,163 (-)NCBIHuRef
CHM1_12224,326,074 - 24,334,537 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on DDT
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353002
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.