Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: HSD17B2 (hydroxysteroid 17-beta dehydrogenase 2) Homo sapiens
Symbol: HSD17B2
Name: hydroxysteroid 17-beta dehydrogenase 2
Description: Exhibits estradiol 17-beta-dehydrogenase activity and testosterone dehydrogenase (NAD+) activity. Involved in response to retinoic acid. Predicted to localize to the endoplasmic reticulum membrane; PARTICIPATES IN estradiol biosynthetic pathway; steroid hormone biosynthetic pathway; testosterone biosynthetic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 17-beta-HSD 2; 17-beta-hydroxysteroid dehydrogenase type 2; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH; EDH17B2; estradiol 17-beta-dehydrogenase 2; HSD17; hydroxysteroid (17-beta) dehydrogenase 2; microsomal 17-beta-hydroxysteroid dehydrogenase; SDR9C2; short chain dehydrogenase/reductase family 9C member 2; short chain dehydrogenase/reductase family 9C, member 2; testosterone 17-beta-dehydrogenase
Mus musculus (house mouse) : Hsd17b2 (hydroxysteroid (17-beta) dehydrogenase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hsd17b2 (hydroxysteroid (17-beta) dehydrogenase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsd17b2 (hydroxysteroid 17-beta dehydrogenase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HSD17B2 (hydroxysteroid 17-beta dehydrogenase 2)
Canis lupus familiaris (dog) : HSD17B2 (hydroxysteroid 17-beta dehydrogenase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsd17b2 (hydroxysteroid 17-beta dehydrogenase 2)
Sus scrofa (pig) : HSD17B2 (hydroxysteroid 17-beta dehydrogenase 2)
Chlorocebus sabaeus (green monkey) : HSD17B2 (hydroxysteroid 17-beta dehydrogenase 2)
Heterocephalus glaber (naked mole-rat) : Hsd17b2 (hydroxysteroid 17-beta dehydrogenase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1682,035,004 - 82,098,534 (+)Ensembl
GRCh381682,035,253 - 82,098,534 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371682,068,842 - 82,132,139 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361680,626,364 - 80,689,638 (+)NCBINCBI36hg18NCBI36
Build 341680,626,363 - 80,689,638NCBI
Celera1666,367,527 - 66,430,804 (+)NCBI
Cytogenetic Map16q23.3NCBI
HuRef1667,822,411 - 67,885,688 (+)NCBIHuRef
CHM1_11683,480,225 - 83,543,515 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HSD17B2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353008
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.