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Gene: MSH3 (mutS homolog 3) Homo sapiens
Symbol: MSH3
Name: mutS homolog 3
Description: Exhibits enzyme binding activity. Contributes to dinucleotide repeat insertion binding activity; single guanine insertion binding activity; and single-stranded DNA binding activity. Involved in DNA metabolic process; negative regulation of DNA recombination; and positive regulation of helicase activity. Localizes to MutSbeta complex. Implicated in colorectal carcinoma; endometrial cancer; endometrial carcinoma; and familial adenomatous polyposis 4.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: divergent upstream protein; DNA mismatch repair protein Msh3; DUP; FAP4; hMSH3; MGC163306; MGC163308; mismatch repair protein 1; MRP1
Mus musculus (house mouse) : Msh3 (mutS homolog 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Msh3 (mutS homolog 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Msh3 (mutS homolog 3)
Pan paniscus (bonobo/pygmy chimpanzee) : MSH3 (mutS homolog 3)
Canis lupus familiaris (dog) : MSH3 (mutS homolog 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Msh3 (mutS homolog 3)
Sus scrofa (pig) : MSH3 (mutS homolog 3)
Chlorocebus sabaeus (African green monkey) : MSH3 (mutS homolog 3)
Heterocephalus glaber (naked mole-rat) : Msh3 (mutS homolog 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl580,654,652 - 80,876,815 (+)EnsemblGRCh38hg38GRCh38
GRCh38580,654,652 - 80,876,815 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37579,950,467 - 80,172,634 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36579,986,050 - 80,208,390 (+)NCBINCBI36hg18NCBI36
Build 34579,986,294 - 80,208,389NCBI
Celera575,854,379 - 76,076,910 (+)NCBI
Cytogenetic Map5q14.1NCBI
HuRef575,159,370 - 75,381,401 (+)NCBIHuRef
CHM1_1579,383,713 - 79,605,325 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on MSH3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353031
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-07-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.