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Gene: BAK1 (BCL2 antagonist/killer 1) Homo sapiens
Symbol: BAK1
Name: BCL2 antagonist/killer 1
Description: Exhibits ion channel binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including activation of cysteine-type endopeptidase activity; cellular response to mechanical stimulus; and regulation of protein heterodimerization activity. Localizes to the BAK complex; mitochondrial outer membrane; and pore complex. Implicated in ataxia telangiectasia and cervix carcinoma. Biomarker of Alzheimer's disease; leiomyoma; and renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apoptosis regulator BAK; BAK; BAK-LIKE; bcl-2 homologous antagonist/killer; bcl-2-like protein 7; BCL2-antagonist/killer 1; bcl2-L-7; BCL2-like 7 protein; BCL2L7; CDN1; MGC117255; MGC3887; pro-apoptotic protein BAK
Mus musculus (house mouse) : Bak1 (BCL2-antagonist/killer 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Bak1 (BCL2-antagonist/killer 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bak1 (BCL2 antagonist/killer 1)
Pan paniscus (bonobo/pygmy chimpanzee) : BAK1 (BCL2 antagonist/killer 1)
Canis lupus familiaris (dog) : BAK1 (BCL2 antagonist/killer 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bak1 (BCL2 antagonist/killer 1)
Sus scrofa (pig) : BAK1 (BCL2 antagonist/killer 1)
more info ...
Related Pseudogenes: BAK1P1   BAK1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38633,572,552 - 33,580,296 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37633,540,323 - 33,548,072 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,648,301 - 33,656,048 (-)NCBINCBI36hg18NCBI36
Build 34633,648,306 - 33,655,959NCBI
Celera635,094,701 - 35,102,448 (-)NCBI
Cytogenetic Map6p21.31NCBI
HuRef633,281,784 - 33,289,531 (-)NCBIHuRef
CHM1_1633,542,641 - 33,550,388 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on BAK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353034
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.