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Gene: BAK1 (BCL2 antagonist/killer 1) Homo sapiens
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Symbol: BAK1
Name: BCL2 antagonist/killer 1
Description: Exhibits ion channel binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including activation of cysteine-type endopeptidase activity; cellular response to mechanical stimulus; and regulation of protein heterodimerization activity. Localizes to the BAK complex; mitochondrial outer membrane; and pore complex. Implicated in ataxia telangiectasia and cervix carcinoma. Biomarker of Alzheimer's disease; leiomyoma; and renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apoptosis regulator BAK; BAK; BAK-LIKE; bcl-2 homologous antagonist/killer; bcl-2-like protein 7; BCL2-antagonist/killer 1; bcl2-L-7; BCL2-like 7 protein; BCL2L7; CDN1; MGC117255; MGC3887; pro-apoptotic protein BAK
Orthologs:
Mus musculus (house mouse) : Bak1 (BCL2-antagonist/killer 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Bak1 (BCL2-antagonist/killer 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bak1 (BCL2 antagonist/killer 1)
Pan paniscus (bonobo/pygmy chimpanzee) : BAK1 (BCL2 antagonist/killer 1)
Canis lupus familiaris (dog) : BAK1 (BCL2 antagonist/killer 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bak1 (BCL2 antagonist/killer 1)
Sus scrofa (pig) : BAK1 (BCL2 antagonist/killer 1)
more info ...
Related Pseudogenes: BAK1P1   BAK1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38633,572,552 - 33,580,296 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37633,540,323 - 33,548,072 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,648,301 - 33,656,048 (-)NCBINCBI36hg18NCBI36
Build 34633,648,306 - 33,655,959NCBI
Celera635,094,701 - 35,102,448 (-)NCBI
Cytogenetic Map6p21.31NCBI
HuRef633,281,784 - 33,289,531 (-)NCBIHuRef
CHM1_1633,542,641 - 33,550,388 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on BAK1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353034
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.