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Gene: SYNGAP1 (synaptic Ras GTPase activating protein 1) Homo sapiens
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Symbol: SYNGAP1
Name: synaptic Ras GTPase activating protein 1
Description: Predicted to have GTPase activator activity and SH3 domain binding activity. Predicted to be involved in negative regulation of Ras protein signal transduction and regulation of synaptic plasticity. Predicted to localize to cytosol. Implicated in autosomal dominant non-syndromic intellectual disability 5.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp761G1421; KIAA1938; MRD5; neuronal RasGAP; ras GTPase-activating protein SynGAP; ras/Rap GTPase-activating protein SynGAP; RASA1; RASA5; synaptic Ras GTPase activating protein 1 homolog; synaptic Ras GTPase activating protein, 135kDa; synaptic Ras GTPase-activating protein 1; SYNGAP
Orthologs:
Mus musculus (house mouse) : Syngap1 (synaptic Ras GTPase activating protein 1 homolog (rat))  MGI  Alliance
Rattus norvegicus (Norway rat) : Syngap1 (synaptic Ras GTPase activating protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Syngap1 (synaptic Ras GTPase activating protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SYNGAP1 (synaptic Ras GTPase activating protein 1)
Canis lupus familiaris (dog) : SYNGAP1 (synaptic Ras GTPase activating protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Syngap1 (synaptic Ras GTPase activating protein 1)
Sus scrofa (pig) : SYNGAP1 (synaptic Ras GTPase activating protein 1)
Chlorocebus sabaeus (African green monkey) : SYNGAP1 (synaptic Ras GTPase activating protein 1)
Heterocephalus glaber (naked mole-rat) : Syngap1 (synaptic Ras GTPase activating protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl633,419,661 - 33,453,689 (+)EnsemblGRCh38hg38GRCh38
GRCh38633,420,065 - 33,453,689 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37633,387,847 - 33,421,466 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,495,825 - 33,529,444 (+)NCBINCBI36hg18NCBI36
Celera634,942,270 - 34,975,892 (+)NCBI
Cytogenetic Map6p21.32NCBI
HuRef633,129,996 - 33,162,361 (+)NCBIHuRef
CHM1_1633,389,741 - 33,423,358 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - uncurated

Genomics

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Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on SYNGAP1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353044
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.