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Gene: ITM2B (integral membrane protein 2B) Homo sapiens
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Symbol: ITM2B
Name: integral membrane protein 2B
Description: Exhibits amyloid-beta binding activity. Involved in negative regulation of amyloid precursor protein biosynthetic process. Localizes to several cellular components, including the Golgi apparatus; Golgi-associated vesicle membrane; and integral component of organelle membrane. Implicated in ITM2B-related cerebral amyloid angiopathy 1 and ITM2B-related cerebral amyloid angiopathy 2. Biomarker of ITM2B-related cerebral amyloid angiopathy 1.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ABRI; ABri/ADan amyloid peptide; BRI; BRI2; BRICD2B; BRICHOS domain containing 2B; E25B; E3-16; FBD; imBRI2; immature BRI2; RDGCA; transmembrane protein BRI
Orthologs:
Mus musculus (house mouse) : Itm2b (integral membrane protein 2B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Itm2b (integral membrane protein 2B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itm2b (integral membrane protein 2B)
Pan paniscus (bonobo/pygmy chimpanzee) : ITM2B (integral membrane protein 2B)
Canis lupus familiaris (dog) : ITM2B (integral membrane protein 2B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itm2b (integral membrane protein 2B)
Sus scrofa (pig) : ITM2B (integral membrane protein 2B)
more info ...
Related Pseudogenes: ITM2BP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381348,233,206 - 48,270,357 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371348,807,274 - 48,836,232 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361347,705,309 - 47,734,228 (+)NCBINCBI36hg18NCBI36
Build 341347,705,306 - 47,734,226NCBI
Celera1329,861,986 - 29,890,942 (+)NCBI
Cytogenetic Map13q14.2NCBI
HuRef1329,599,469 - 29,628,426 (+)NCBIHuRef
CHM1_11348,774,975 - 48,803,938 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on ITM2B
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353059
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.