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Gene: ITM2B (integral membrane protein 2B) Homo sapiens
Symbol: ITM2B
Name: integral membrane protein 2B
Description: Exhibits amyloid-beta binding activity. Involved in negative regulation of amyloid precursor protein biosynthetic process. Localizes to several cellular components, including the Golgi apparatus; Golgi-associated vesicle membrane; and integral component of organelle membrane. Implicated in ITM2B-related cerebral amyloid angiopathy 1 and ITM2B-related cerebral amyloid angiopathy 2. Biomarker of ITM2B-related cerebral amyloid angiopathy 1.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ABRI; ABri/ADan amyloid peptide; BRI; BRI2; BRICD2B; BRICHOS domain containing 2B; E25B; E3-16; FBD; imBRI2; immature BRI2; RDGCA; transmembrane protein BRI
Mus musculus (house mouse) : Itm2b (integral membrane protein 2B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Itm2b (integral membrane protein 2B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itm2b (integral membrane protein 2B)
Pan paniscus (bonobo/pygmy chimpanzee) : ITM2B (integral membrane protein 2B)
Canis lupus familiaris (dog) : ITM2B (integral membrane protein 2B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itm2b (integral membrane protein 2B)
Sus scrofa (pig) : ITM2B (integral membrane protein 2B)
more info ...
Related Pseudogenes: ITM2BP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381348,233,206 - 48,270,357 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371348,807,274 - 48,836,232 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361347,705,309 - 47,734,228 (+)NCBINCBI36hg18NCBI36
Build 341347,705,306 - 47,734,226NCBI
Celera1329,861,986 - 29,890,942 (+)NCBI
Cytogenetic Map13q14.2NCBI
HuRef1329,599,469 - 29,628,426 (+)NCBIHuRef
CHM1_11348,774,975 - 48,803,938 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on ITM2B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353059
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.