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Gene: LRRK2 (leucine rich repeat kinase 2) Homo sapiens
Symbol: LRRK2
Name: leucine rich repeat kinase 2
Description: Exhibits several functions, including cytoskeletal protein binding activity; enzyme regulator activity; and protein kinase activity. Involved in several processes, including protein phosphorylation; regulation of nervous system development; and regulation of signal transduction. Localizes to several cellular components, including Wnt signalosome; autophagosome; and cytoplasmic vesicle. Implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; and cancer. Biomarker of Parkinson's disease; amyotrophic lateral sclerosis; frontotemporal dementia; and rheumatoid arthritis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: augmented in rheumatoid arthritis 17; AURA17; DARDARIN; leucine-rich repeat kinase 2; leucine-rich repeat serine/threonine-protein kinase 2; PARK8; Parkinson disease (autosomal dominant) 8; RIPK7; ROCO2
Mus musculus (house mouse) : Lrrk2 (leucine-rich repeat kinase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lrrk2 (leucine-rich repeat kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrrk2 (leucine rich repeat kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LRRK2 (leucine rich repeat kinase 2)
Canis lupus familiaris (dog) : LRRK2 (leucine rich repeat kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrrk2 (leucine rich repeat kinase 2)
Sus scrofa (pig) : LRRK2 (leucine rich repeat kinase 2)
Chlorocebus sabaeus (African green monkey) : LRRK2 (leucine rich repeat kinase 2)
Heterocephalus glaber (naked mole-rat) : Lrrk2 (leucine rich repeat kinase 2)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: Strains:   SD-Tg(LRRK2*R1441C)268Rwm   SD-Tg(LRRK2*G2019S)418Rwm   SD-Tg(LRRK2)302Rwn  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1240,196,744 - 40,369,285 (+)EnsemblGRCh38hg38GRCh38
GRCh381240,224,890 - 40,369,285 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371240,618,813 - 40,763,087 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361238,905,081 - 39,049,354 (+)NCBINCBI36hg18NCBI36
Celera1239,422,059 - 39,566,110 (+)NCBI
Cytogenetic Map12q12NCBI
HuRef1237,646,624 - 37,790,676 (+)NCBIHuRef
CHM1_11240,584,126 - 40,728,194 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers