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Gene: MARK3 (microtubule affinity regulating kinase 3) Homo sapiens
Symbol: MARK3
Name: microtubule affinity regulating kinase 3
Description: Exhibits protein serine/threonine kinase activity and tau-protein kinase activity. Involved in negative regulation of hippo signaling; peptidyl-serine autophosphorylation; and positive regulation of protein binding activity. Localizes to the cytoplasm; dendrite; and plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C-TAK1; cdc25C-associated protein kinase 1; CTAK1; ELKL motif kinase 2; EMK-2; KP78; MAP/microtubule affinity-regulating kinase 3; Par-1a; PAR1A; protein kinase STK10; ser/Thr protein kinase PAR-1; serine/threonine-protein kinase p78; VIPB
Mus musculus (house mouse) : Mark3 (MAP/microtubule affinity regulating kinase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mark3 (microtubule affinity regulating kinase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mark3 (microtubule affinity regulating kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : MARK3 (microtubule affinity regulating kinase 3)
Canis lupus familiaris (dog) : MARK3 (microtubule affinity regulating kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mark3 (microtubule affinity regulating kinase 3)
Sus scrofa (pig) : MARK3 (microtubule affinity regulating kinase 3)
more info ...
Related Pseudogenes: MARK3P1   MARK3P2   MARK3P3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl14103,385,392 - 103,503,831 (+)Ensembl
GRCh3814103,385,364 - 103,503,831 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714103,851,701 - 103,970,168 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614102,921,524 - 103,039,921 (+)NCBINCBI36hg18NCBI36
Build 3414102,921,523 - 103,039,917NCBI
Celera1483,905,890 - 84,024,379 (+)NCBI
Cytogenetic Map14q32.32-q32.33NCBI
HuRef1484,029,889 - 84,148,541 (+)NCBIHuRef
CHM1_114103,789,889 - 103,908,361 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on MARK3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353156
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.