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Gene: AURKA (aurora kinase A) Homo sapiens
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Symbol: AURKA
Name: aurora kinase A
Description: Exhibits protein heterodimerization activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including liver regeneration; peptidyl-serine phosphorylation; and regulation of protein stability. Localizes to several cellular components, including the nucleoplasm; perinuclear region of cytoplasm; and spindle pole. Colocalizes with the spindle microtubule. Implicated in ovarian cancer and uterine cancer. Biomarker of carcinoma (multiple); invasive ductal carcinoma; prostate carcinoma in situ; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AIK; ARK-1; ARK1; AURA; aurora 2; Aurora-A kinase; aurora-related kinase 1; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; AURORA2; breast tumor-amplified kinase; breast-tumor-amplified kinase; BTAK; hARK1; IPL1-related kinase; MGC34538; PPP1R47; protein phosphatase 1, regulatory subunit 47; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine-protein kinase 15; serine/threonine-protein kinase 6; serine/threonine-protein kinase aurora-A; STK15; STK6; STK7
Orthologs:
Mus musculus (house mouse) : Aurka (aurora kinase A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Aurka (aurora kinase A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aurka (aurora kinase A)
Pan paniscus (bonobo/pygmy chimpanzee) : AURKA (aurora kinase A)
Canis lupus familiaris (dog) : AURKA (aurora kinase A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aurka (aurora kinase A)
Sus scrofa (pig) : AURKA (aurora kinase A)
more info ...
Related Pseudogenes: AURKAP1   AURKAP2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382056,369,389 - 56,392,337 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372054,944,445 - 54,967,351 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362054,377,852 - 54,400,758 (-)NCBINCBI36hg18NCBI36
Celera2051,683,792 - 51,707,784 (-)NCBI
Cytogenetic Map20q13.2NCBI
HuRef2051,729,262 - 51,752,229 (-)NCBIHuRef
CHM1_12054,845,539 - 54,868,486 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on AURKA
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353168
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.