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Gene: SPCS3 (signal peptidase complex subunit 3) Homo sapiens
Symbol: SPCS3
Name: signal peptidase complex subunit 3
Description: Predicted to have peptidase activity. Involved in proteolysis and viral protein processing. Localizes to endoplasmic reticulum; INTERACTS WITH (-)-epigallocatechin 3-gallate; 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one; 17beta-hydroxy-5alpha-androstan-3-one.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DKFZp564J1864; FLJ22649; microsomal signal peptidase 22/23 kDa subunit; microsomal signal peptidase 23 kDa subunit; PRO3567; signal peptidase complex subunit 3 homolog; SPase 22 kDa subunit; SPase 22/23 kDa subunit; SPC22; SPC22/23; SPC23; SPC3; YLR066W
Mus musculus (house mouse) : Spcs3 (signal peptidase complex subunit 3 homolog (S. cerevisiae))  MGI  Alliance
Rattus norvegicus (Norway rat) : Spcs3 (signal peptidase complex subunit 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spcs3 (signal peptidase complex subunit 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SPCS3 (signal peptidase complex subunit 3)
Canis lupus familiaris (dog) : SPCS3 (signal peptidase complex subunit 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spcs3 (signal peptidase complex subunit 3)
Sus scrofa (pig) : SPCS3 (signal peptidase complex subunit 3)
Chlorocebus sabaeus (African green monkey) : SPCS3 (signal peptidase complex subunit 3)
Heterocephalus glaber (naked mole-rat) : Spcs3 (signal peptidase complex subunit 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl4176,319,966 - 176,332,245 (+)EnsemblGRCh38hg38GRCh38
GRCh384176,319,966 - 176,332,245 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374177,241,090 - 177,253,396 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364177,478,109 - 177,487,348 (+)NCBINCBI36hg18NCBI36
Build 344177,616,263 - 177,625,501NCBI
Celera4174,568,936 - 174,581,241 (+)NCBI
Cytogenetic Map4q34.2NCBI
HuRef4172,992,124 - 173,004,427 (+)NCBIHuRef
CHM1_14177,217,493 - 177,229,799 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SPCS3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353202
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.