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Gene: F2 (coagulation factor II, thrombin) Homo sapiens
Symbol: F2
Name: coagulation factor II, thrombin
Description: Exhibits several functions, including heparin binding activity; lipopolysaccharide binding activity; and serine-type endopeptidase activity. Involved in several processes, including killing by host of symbiont cells; positive regulation of cellular metabolic process; and regulation of blood coagulation. Localizes to the extracellular space. Colocalizes with the external side of plasma membrane. Implicated in several diseases, including X-linked recessive disease (multiple); appendicitis; artery disease (multiple); autoimmune hypersensitivity disease (multiple); and osteonecrosis. Biomarker of several diseases, including Chagas disease; autoimmune hypersensitivity disease (multiple); glucose metabolism disease (multiple); inflammatory bowel disease (multiple); and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: coagulation factor II; coagulation factor II (thrombin); prepro-coagulation factor II; prothrombin; prothrombin B-chain; PT; RPRGL2; serine protease; THPH1; thrombin factor II
Mus musculus (house mouse) : F2 (coagulation factor II)  MGI  Alliance
Rattus norvegicus (Norway rat) : F2 (coagulation factor II)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : F2 (coagulation factor II, thrombin)
Pan paniscus (bonobo/pygmy chimpanzee) : F2 (coagulation factor II, thrombin)
Canis lupus familiaris (dog) : F2 (coagulation factor II, thrombin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : F2 (coagulation factor II, thrombin)
Sus scrofa (pig) : F2 (coagulation factor II, thrombin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1146,719,196 - 46,739,506 (+)Ensembl
GRCh38 Ensembl1146,719,180 - 46,739,506 (+)Ensembl
GRCh381146,719,201 - 46,739,506 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371146,740,743 - 46,761,056 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361146,697,331 - 46,717,631 (+)NCBINCBI36hg18NCBI36
Build 341146,697,330 - 46,717,631NCBI
Celera1146,888,702 - 46,909,014 (+)NCBI
Cytogenetic Map11p11.2NCBI
HuRef1146,446,660 - 46,466,973 (+)NCBIHuRef
CHM1_11146,739,122 - 46,759,464 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on F2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353256
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-01-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.