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Gene: CCL4 (C-C motif chemokine ligand 4) Homo sapiens
Symbol: CCL4
Name: C-C motif chemokine ligand 4
Description: Exhibits CCR1 chemokine receptor binding activity; CCR5 chemokine receptor binding activity; and identical protein binding activity. Involved in several processes, including negative regulation by host of viral transcription; positive regulation of calcium-mediated signaling; and positive regulation of natural killer cell chemotaxis. Predicted to localize to the extracellular space. Implicated in acquired immunodeficiency syndrome. Biomarker of several diseases, including Plasmodium falciparum malaria; bone disease (multiple); lung disease (multiple); nose disease (multiple); and rheumatic disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACT2; AT744.1; C-C motif chemokine 4; CC chemokine ligand 4; chemokine (C-C motif) ligand 4; G-26; G-26 T-lymphocyte-secreted protein; HC21; LAG-1; LAG1; lymphocyte activation gene 1 protein; lymphocyte-activation gene 1; macrophage inflammatory protein 1-beta; MGC104418; MGC126025; MGC126026; MIP-1-beta; MIP-1-beta(1-69); MIP1B; MIP1B1; PAT 744; SCYA2; SCYA4; secreted protein G-26; SIS-gamma; small inducible cytokine A4 (homologous to mouse Mip-1b); small-inducible cytokine A4; T-cell activation protein 2
Mus musculus (house mouse) : Ccl4 (chemokine (C-C motif) ligand 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ccl4 (C-C motif chemokine ligand 4)  Alliance
Canis lupus familiaris (dog) : CCL4 (chemokine (C-C motif) ligand 4)
Sus scrofa (pig) : CCL4 (C-C motif chemokine ligand 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1736,103,827 - 36,105,621 (+)EnsemblGRCh38hg38GRCh38
GRCh381736,103,827 - 36,105,614 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371734,431,220 - 34,433,014 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361731,455,333 - 31,457,127 (+)NCBINCBI36hg18NCBI36
Build 341731,455,332 - 31,457,127NCBI
Celera1731,340,772 - 31,342,566 (+)NCBI
Cytogenetic Map17q12NCBI
HuRef1730,615,959 - 30,617,753 (+)NCBIHuRef
CHM1_11734,495,398 - 34,497,192 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CCL4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353278
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.