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Gene: TLR7 (toll like receptor 7) Homo sapiens
Symbol: TLR7
Name: toll like receptor 7
Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: TLR7-like; toll-like receptor 7; toll-like receptor 7-like
Mus musculus (house mouse) : Tlr7 (toll-like receptor 7)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tlr7 (toll-like receptor 7)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlr7 (toll like receptor 7)
Pan paniscus (bonobo/pygmy chimpanzee) : TLR7 (toll like receptor 7)
Canis lupus familiaris (dog) : TLR7 (toll like receptor 7)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlr7 (toll like receptor 7)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X12,867,072 - 12,890,361 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X12,885,202 - 12,908,480 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X12,795,123 - 12,818,401 (+)NCBINCBI36hg18NCBI36
Build 34X12,644,862 - 12,666,567NCBI
CeleraX16,999,208 - 17,022,486 (+)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX10,651,692 - 10,675,129 (+)NCBIHuRef
CHM1_1X12,915,641 - 12,938,921 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TLR7
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353456
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.