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Gene: PDLIM4 (PDZ and LIM domain 4) Homo sapiens
Symbol: PDLIM4
Name: PDZ and LIM domain 4
Description: Exhibits alpha-actinin binding activity; protein homodimerization activity; and protein phosphatase binding activity. Involved in actin cytoskeleton reorganization. Localizes to several cellular components, including the actin cytoskeleton; lamellipodium; and perinuclear region of cytoplasm. Implicated in osteoporosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: enigma homolog; LIM domain protein; LIM protein RIL; PDZ and LIM domain protein 4; reversion-induced LIM protein; RIL
Mus musculus (house mouse) : Pdlim4 (PDZ and LIM domain 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pdlim4 (PDZ and LIM domain 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdlim4 (PDZ and LIM domain 4)
Pan paniscus (bonobo/pygmy chimpanzee) : PDLIM4 (PDZ and LIM domain 4)
Canis lupus familiaris (dog) : PDLIM4 (PDZ and LIM domain 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdlim4 (PDZ and LIM domain 4)
Sus scrofa (pig) : PDLIM4 (PDZ and LIM domain 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl5132,257,696 - 132,273,454 (+)Ensembl
GRCh385132,257,658 - 132,273,454 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375131,593,351 - 131,609,147 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,621,286 - 131,637,046 (+)NCBINCBI36hg18NCBI36
Build 345131,621,285 - 131,637,046NCBI
Celera5127,723,467 - 127,739,259 (+)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5126,785,601 - 126,801,399 (+)NCBIHuRef
CHM1_15131,026,116 - 131,041,912 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on PDLIM4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353458
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.