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Gene: XIST (X inactive specific transcript) Homo sapiens
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Symbol: XIST
Name: X inactive specific transcript
Description: X inactivation is an early developmental process in mammalian females that transcriptionally silences one of the pair of X chromosomes, thus providing dosage equivalence between males and females. The process is regulated by several factors, including a region of chromosome X called the X inactivation center (XIC). The XIC comprises several non-coding and protein-coding genes, and this gene was the first non-coding gene identified within the XIC. This gene is expressed exclusively from the XIC of the inactive X chromosome, and is essential for the initiation and spread of X-inactivation. The transcript is a spliced RNA. Alternatively spliced transcript variants have been identified, but their full length sequences have not been determined. Mutations in the XIST promoter cause familial skewed X inactivation. [provided by RefSeq, Apr 2012]
Type: ncrna
RefSeq Status: REVIEWED
Also known as: DKFZp779P0129; DXS1089; DXS399E; LINC00001; NCRNA00001; swd66; SXI1; X inactive specific transcript (non-protein coding); XCE; XIC
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X73,820,651 - 73,852,753 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X73,040,486 - 73,072,588 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X72,957,220 - 72,989,313 (-)NCBINCBI36hg18NCBI36
CeleraX73,323,975 - 73,356,069 (-)NCBI
Cytogenetic MapXq13.2NCBI
HuRefX66,674,711 - 66,706,299 (-)NCBIHuRef
CHM1_1X72,933,265 - 72,965,330 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on XIST
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353468
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-17
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.