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Gene: XIST (X inactive specific transcript) Homo sapiens
Symbol: XIST
Name: X inactive specific transcript
Description: X inactivation is an early developmental process in mammalian females that transcriptionally silences one of the pair of X chromosomes, thus providing dosage equivalence between males and females. The process is regulated by several factors, including a region of chromosome X called the X inactivation center (XIC). The XIC comprises several non-coding and protein-coding genes, and this gene was the first non-coding gene identified within the XIC. This gene is expressed exclusively from the XIC of the inactive X chromosome, and is essential for the initiation and spread of X-inactivation. The transcript is a spliced RNA. Alternatively spliced transcript variants have been identified, but their full length sequences have not been determined. Mutations in the XIST promoter cause familial skewed X inactivation. [provided by RefSeq, Apr 2012]
Type: ncrna
RefSeq Status: REVIEWED
Also known as: DKFZp779P0129; DXS1089; DXS399E; LINC00001; NCRNA00001; swd66; SXI1; X inactive specific transcript (non-protein coding); XCE; XIC
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X73,820,651 - 73,852,753 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X73,040,486 - 73,072,588 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X72,957,220 - 72,989,313 (-)NCBINCBI36hg18NCBI36
CeleraX73,323,975 - 73,356,069 (-)NCBI
Cytogenetic MapXq13.2NCBI
HuRefX66,674,711 - 66,706,299 (-)NCBIHuRef
CHM1_1X72,933,265 - 72,965,330 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on XIST
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353468
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-17
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.