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Gene: GZMB (granzyme B) Homo sapiens
Symbol: GZMB
Name: granzyme B
Description: Exhibits serine-type endopeptidase activity. Involved in natural killer cell mediated cytotoxicity. Localizes to the membrane. Biomarker of bronchiolitis obliterans and chronic obstructive pulmonary disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C11; cathepsin G-like 1; CCPI; CGL-1; CGL1; CSP-B; CSPB; CTLA-1; CTLA1; CTSGL1; cytotoxic serine protease B; cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; fragmentin 2; fragmentin-2; granzyme 2; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme-2; HLP; human lymphocyte protein; lymphocyte protease; SECT; T-cell serine protease 1-3E
Mus musculus (house mouse) : Gzmb (granzyme B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gzmb (granzyme B)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : GZMB (granzyme B)
Canis lupus familiaris (dog) : GZMB (granzyme B)
Sus scrofa (pig) : GZMB (granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1))
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1424,630,954 - 24,634,267 (-)Ensembl
GRCh381424,630,954 - 24,634,190 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371425,100,160 - 25,103,490 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361424,170,000 - 24,173,272 (-)NCBINCBI36hg18NCBI36
Build 341424,170,003 - 24,173,272NCBI
Celera144,964,951 - 4,968,224 (-)NCBI
Cytogenetic Map14q12NCBI
HuRef145,214,872 - 5,218,144 (-)NCBIHuRef
CHM1_11425,099,053 - 25,102,325 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GZMB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353495
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.