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Gene: GAB3 (GRB2 associated binding protein 3) Homo sapiens
Symbol: GAB3
Name: GRB2 associated binding protein 3
Description: This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DOS/Gab family member 3; Gab3 scaffolding protein; GRB2-associated binder 3; GRB2-associated binding protein 3; GRB2-associated-binding protein 3; growth factor receptor bound protein 2-associated protein 3
Mus musculus (house mouse) : Gab3 (growth factor receptor bound protein 2-associated protein 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gab3 (GRB2 associated binding protein 3)
Pan paniscus (bonobo/pygmy chimpanzee) : GAB3 (GRB2 associated binding protein 3)
Canis lupus familiaris (dog) : GAB3 (GRB2 associated binding protein 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gab3 (GRB2 associated binding protein 3)
Sus scrofa (pig) : GAB3 (GRB2 associated binding protein 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X154,675,249 - 154,751,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X153,903,526 - 153,979,855 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,556,720 - 153,632,542 (-)NCBINCBI36hg18NCBI36
Build 34X153,467,233 - 153,543,036NCBI
CeleraX154,061,594 - 154,137,916 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX142,447,630 - 142,523,043 (-)NCBIHuRef
CHM1_1X153,815,233 - 153,891,531 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GAB3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353554
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.