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Gene: GAB3 (GRB2 associated binding protein 3) Homo sapiens
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Symbol: GAB3
Name: GRB2 associated binding protein 3
Description: This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DOS/Gab family member 3; Gab3 scaffolding protein; GRB2-associated binder 3; GRB2-associated binding protein 3; GRB2-associated-binding protein 3; growth factor receptor bound protein 2-associated protein 3
Orthologs:
Mus musculus (house mouse) : Gab3 (growth factor receptor bound protein 2-associated protein 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gab3 (GRB2 associated binding protein 3)
Pan paniscus (bonobo/pygmy chimpanzee) : GAB3 (GRB2 associated binding protein 3)
Canis lupus familiaris (dog) : GAB3 (GRB2 associated binding protein 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gab3 (GRB2 associated binding protein 3)
Sus scrofa (pig) : GAB3 (GRB2 associated binding protein 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,675,249 - 154,751,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X153,903,526 - 153,979,855 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,556,720 - 153,632,542 (-)NCBINCBI36hg18NCBI36
Build 34X153,467,233 - 153,543,036NCBI
CeleraX154,061,594 - 154,137,916 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX142,447,630 - 142,523,043 (-)NCBIHuRef
CHM1_1X153,815,233 - 153,891,531 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on GAB3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353554
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.