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Gene: SPANXB1 (SPANX family member B1) Homo sapiens
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Symbol: SPANXB1
Name: SPANX family member B1
Description: Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular family member contains an additional 18 nucleotides in its coding region compared to the other family members in the same gene cluster. This family member is also subject to gene copy number variation. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis. [provided by RefSeq, Apr 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: B1; cancer/testis antigen 11.2; cancer/testis antigen family 11, member 2; CT11.2; nuclear-associated protein SPAN-Xb; nuclear-associated protein SPAN-Xf; SPAN-Xf; SPANX family member B/F; SPANX family member F1; SPANX family, member B1; SPANX family, member B2; SPANX family, member F1; SPANX family, member F2; SPANX-B; SPANX-F; SPANXB; SPANXB2; SPANXF1; SPANXF2; sperm protein associated with the nucleus on the X chromosome B/F; sperm protein associated with the nucleus on the X chromosome B1; sperm protein associated with the nucleus, X chromosome, family member B1
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X141,002,591 - 141,003,706 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X140,096,761 - 140,097,876 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X139,924,427 - 139,925,545 (+)NCBINCBI36hg18NCBI36
Build 34X139,822,280 - 139,823,395NCBI
CeleraX140,458,407 - 140,458,599 (+)NCBI
Cytogenetic MapXq27.1NCBI
HuRefX129,338,398 - 129,354,824 (+)NCBIHuRef
CHM1_1X140,008,422 - 140,009,537 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SPANXB1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353572
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.