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Gene: CDKL5 (cyclin dependent kinase like 5) Homo sapiens
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Symbol: CDKL5
Name: cyclin dependent kinase like 5
Description: This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CFAP247; cyclin dependent kinase 5 transcript; cyclin-dependent kinase-like 5; EIEE2; ISSX; serine/threonine kinase 9; serine/threonine-protein kinase 9; STK9
Orthologs:
Mus musculus (house mouse) : Cdkl5 (cyclin-dependent kinase-like 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cdkl5 (cyclin-dependent kinase-like 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdkl5 (cyclin dependent kinase like 5)
Pan paniscus (bonobo/pygmy chimpanzee) : CDKL5 (cyclin dependent kinase like 5)
Canis lupus familiaris (dog) : CDKL5 (cyclin dependent kinase like 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdkl5 (cyclin dependent kinase like 5)
Sus scrofa (pig) : CDKL5 (cyclin dependent kinase like 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X18,425,605 - 18,653,629 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X18,443,725 - 18,671,749 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X18,353,646 - 18,581,670 (+)NCBINCBI36hg18NCBI36
Build 34X18,203,413 - 18,431,402NCBI
CeleraX22,563,823 - 22,791,841 (+)NCBI
Cytogenetic MapXp22.13NCBI
HuRefX16,199,185 - 16,425,423 (+)NCBIHuRef
CHM1_1X18,474,049 - 18,702,829 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CDKL5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1353625
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.